Hospitals in US sound alarm on impending chemotherapy shortages

Doctors say it would be ‘national tragedy’ if patients denied life-extending drugs
Source: FT.com - Drugs and Healthcare - Category: Pharmaceuticals Source Type: news

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Conclusions: AEE protected against 5-Fu-induced intestinal mucositis (IM) in mice through mechanisms that involved in promoting the enterocyte proliferative activity, maintaining the integrity of tight junction proteins, inhibiting oxidative stress and ameliorating the inflammatory disturbances. Accordingly, A. agallocha may be a promising therapeutic candidate used for the prevention of IM during cancer chemotherapy.Graphical abstractThe results of this study gave a scientific support for the protection of AEE on 5-Fu-induced IM in mice through mechanisms that involved in promoting the enterocyte proliferative activity, m...
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
CONCLUSION: The polymorphism of MTHFR C677T/A1298C may not be an important indicator for the accurate detection of side effects of chemotherapy after using MTX. More relative research is needed. PMID: 30024839 [PubMed - as supplied by publisher]
Source: Hematology - Category: Hematology Tags: Hematology Source Type: research
CONCLUSIONS: STAT3 over-expression is associated with DDP resistance in cervical cancer. Decreasing STAT3 can significantly promote the apoptosis of cervical cancer CaSki cells and decrease the DDP resistance. PMID: 30024597 [PubMed - in process]
Source: European Review for Medical and Pharmacological Sciences - Category: Drugs & Pharmacology Tags: Eur Rev Med Pharmacol Sci Source Type: research
AngioDynamics (NSDQ:ANGO) agreed to pay a total of nearly $13 million to settle charges that it broke the False Claims Act for a chemotherapy delivery device and a peripheral vein treatment. Latham, N.Y.-based AngioDynamics distributed the LC Bead embolization microspheres made by BTG (LON:BTG) subsidiary Biocompatibles. Although cleared for embolizations, the companies allegedly marketed LC Bead from May 2006 through December 2011 as a drug-delivery vehicle for chemotherapy agents, according to federal prosecutors in New York and Texas. The company admitted no liability in agreeing to the settlements, they ...
Source: Mass Device - Category: Medical Devices Authors: Tags: Drug-Device Combinations Legal News AngioDynamics Source Type: news
ConclusionThis international survey demonstrates that CRS and HIPEC is now performed on a large scale for CRC-PM patients. Variation in treatment may result in heterogeneity in surgical and oncological outcomes, emphasising the necessity to reach consensus on several issues of this comprehensive procedure. Future initiatives directed at achieving an international consensus statement are needed.
Source: European Journal of Surgical Oncology (EJSO) - Category: Surgery Source Type: research
Condition:   Non-Small Cell Lung Cancer Interventions:   Drug: Tislelizumab Carboplatin Paxlitaxel;   Drug: Tislelizumab Carboplatin Nab-paxlitaxel;   Drug: Carboplatin Paclitaxel Sponsor:   BeiGene Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Rectal Adenocarcinoma;   Stage II Rectal Cancer AJCC v8;   Stage IIA Rectal Cancer AJCC v8;   Stage IIB Rectal Cancer AJCC v8;   Stage IIC Rectal Cancer AJCC v8;   Stage III Rectal Cancer AJCC v8;   Stage IIIA Rectal Cancer AJCC v8;   Stage IIIB Rectal Ca ncer AJCC v8;   Stage IIIC Rectal Cancer AJCC v8 Interventions:   Drug: Chemotherapy;   Other:&...
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Authors: Silva-Pinto A, Rocha-Pereira N, Andrade J, Sarmento A, Santos L Abstract Patients with haematological malignancies have a higher incidence of infection compared with the general population. Several factors contribute to this but specially chemotherapy drugs carry different and specific infectious risks. This protocol discusses the prevention of infections in patients who will undergo chemotherapy for the treatment of haematological malignancies. It is divided into: study prior to the initiation of chemotherapy; vaccination and eradication prior to initiation of chemotherapy; antimicrobial prophylaxis durin...
Source: Acta Medica Portuguesa - Category: General Medicine Tags: Acta Med Port Source Type: research
Conclusions: Ovarian metastases are less responsive to systemic chemotherapy compared to extra-ovarian metastases in patients with relapsed or metastatic colorectal cancer. Multidisciplinary treatment strategy, including systemic chemotherapy and cytoreductive surgery, may contribute to the prolongation of OS.Oncology
Source: Oncology - Category: Cancer & Oncology Source Type: research
The emergence and spread of drug-resistant strains ofMycobacterium tuberculosis is worsening the global threat of tuberculosis (TB). There is a need and urgency for the development of new treatments for TB, for the management of drug resistant TB (MDR-TB) and for improved regimens against drug-susceptible TB, with the goal of reducing toxicity and length of therapy that will boost patience compliance. The paucity of new drugs is a major obstacle to design new regimens while host-directed therapies (HDTs) are emerging as a promising area of research and are opening new avenues to fight TB. In this review, we discuss example...
Source: Chemotherapy - Category: Cancer & Oncology Source Type: research
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