Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders.

Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders. Biochimie. 2018 May 03;: Authors: Grayaa S, Zerbinati C, Messedi M, HadjKacem I, Chtourou M, Ben Touhemi D, Naifar M, Ayadi H, Ayedi F, Iuliano L Abstract Cholesterol and its oxygenated metabolites, such as oxysterols, are intensively investigated as potential players in the pathophysiology of brain disorder. Altered oxysterol levels have been described in patients with numerous neuropsychiatric disorders, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Parkinson's disease, X-linked adrenoleukodystrophy, and Smith-Lemli-Opitz Syndrome. Recent studies have shown that Autism Spectrum Disorders are associated with disruption of cholesterol metabolism. The present study aimed at investigating the profile of oxysterols in plasma and their association with clinical parameters in patients with Autism Spectrum Disorders. Thirty-six children with Autism Spectrum Disorders and thirty-eight healthy children, from Sfax (a southern area of Tunisia) matched for age and sex, were included in the study. The severity of Autism Spectrum Disorders was evaluated using the childhood autism rating scale. Standard lipid profile (total cholesterol, triglycerides, and high-density lipoprotein-cholesterol), serum glucose, high-sensitive C-reactive protein, and orosomucoid levels were measured utilizing standard techniques; oxysterol levels were m...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research

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The present study provides actual data with regard to the prevalence of myocardial ischemia among patients under contemporary cardiovascular prevention strategies undergoing peripheral vascular interventions. We included a total of 200 consecutive patients who underwent gated single-photon emission computed tomography myocardial perfusion study between January 2012 and January 2014 as preoperative evaluation for peripheral vascular interventions at our institution. The baseline medical treatment comprised aspirin (81%), statins (79%), and β-blockers (54%). Thirty-two (16%) patients underwent carotid revascularization;...
Source: Nuclear Medicine Communications - Category: Nuclear Medicine Tags: Original Articles Source Type: research
Publication date: Available online 15 August 2018Source: Progress in Neuro-Psychopharmacology and Biological PsychiatryAuthor(s): Angélica Torres-Berrio, Mauricio O. Nava-MesaAbstractCognitive and emotional impairment are a serious consequence of stress exposure and are core features of neurological and psychiatric conditions that involve memory disorders. Indeed, acute and chronic stress are high-risk factors for the onset of posttraumatic stress disorder (PTSD) and Alzheimer’s disease (AD), two devastating brain disorders associated with memory dysfunction. Besides the sympathetic nervous system and the hypo...
Source: Progress in Neuro Psychopharmacology and Biological Psychiatry - Category: Psychiatry Source Type: research
Publication date: Available online 14 August 2018Source: Journal of Neuroscience MethodsAuthor(s): Matthew S. Binder, Christian J. Hernandez-Zegada, Christian T. Potter, Nolan O. Suzanne, Joaquin N. LugoAbstractAlterations in early-life communicative behaviors are a common feature of neurodevelopmental conditions such as autism and epilepsy. One method of investigating communication in murine models is through analyzing ultrasonic vocalizations. These vocalizations are commonly recorded with either the Avisoft or the Ultravox recording programs. However, since no study has compared whether the systems are equally sensitive...
Source: Journal of Neuroscience Methods - Category: Neuroscience Source Type: research
CONCLUSIONS In a transgenic mouse model of AD, miR-137 and expression of the CACNA1C gene inhibited the hyperphosphorylation of tau protein. PMID: 30102687 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
In this study, we investigate the comorbidities and survival rates of patients with CLI who receive conservative treatment. Thirty-five patients with CLI due to ASO, who had not undergone revascularization surgery (C group), were enrolled. As controls, 136 patients with CLI due to ASO who did undergo revascularization (R group), mainly via bypass surgery, were enrolled. Coronary artery disease, heart failure, and respiratory dysfunction were factors indicating conservative treatment. Limb salvage rates and survival rates were not significantly different between the two groups. Patients who had survived for less than two ye...
Source: International Heart Journal - Category: Cardiology Tags: Int Heart J Source Type: research
Inflammation has been found to be associated with many neurodegenerative diseases, including Parkinson ’s and dementia. Attenuation of microglia-induced inflammation is a strategy that impedes the progression o...
Source: BMC Complementary and Alternative Medicine - Category: Complementary Medicine Authors: Tags: Research article Source Type: research
Conclusions:DORAs offer an additional treatment option for insomnia. More clinical trials are needed to robustly evaluate their safety and effectiveness in several subclasses of individuals with insomnia. Given the published literature, head-to-head comparisons to existing treatment for insomnia are warranted.Citation:Janto K, Prichard JR, Pusalavidyasagar S. An update on dual orexin receptor antagonists and their potential role in insomnia therapeutics.J Clin Sleep Med. 2018;14(8):1399–1408.
Source: Journal of Clinical Sleep Medicine : JCSM - Category: Sleep Medicine Source Type: research
Conclusion: Substantial appearance variation among generically equivalent products raises the strong possibility that patients may experience product switches that could increase the likelihood of nonadherence. Our data support the need to further study drug appearance changes and interventions as a potential factor affecting chronic disease adherence outcomes. PMID: 30100689 [PubMed]
Source: P and T - Category: Drugs & Pharmacology Tags: P T Source Type: research
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Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
Publication date: Available online 14 August 2018Source: NeuroImage: ClinicalAuthor(s): Annegreet van Opbroek, Hakim C. Achterberg, Meike W. Vernooij, M. Arfan Ikram, Marleen de Bruijne, Alzheimer's Disease Neuroimaging InitiativeAbstractMany successful approaches in MR brain segmentation use supervised voxel classification, which requires manually labeled training images that are representative of the test images to segment. However, the performance of such methods often deteriorates if training and test images are acquired with different scanners or scanning parameters, since this leads to differences in feature represen...
Source: NeuroImage: Clinical - Category: Radiology Source Type: research
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