Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders.

Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders. Biochimie. 2018 May 03;: Authors: Grayaa S, Zerbinati C, Messedi M, HadjKacem I, Chtourou M, Ben Touhemi D, Naifar M, Ayadi H, Ayedi F, Iuliano L Abstract Cholesterol and its oxygenated metabolites, such as oxysterols, are intensively investigated as potential players in the pathophysiology of brain disorder. Altered oxysterol levels have been described in patients with numerous neuropsychiatric disorders, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Parkinson's disease, X-linked adrenoleukodystrophy, and Smith-Lemli-Opitz Syndrome. Recent studies have shown that Autism Spectrum Disorders are associated with disruption of cholesterol metabolism. The present study aimed at investigating the profile of oxysterols in plasma and their association with clinical parameters in patients with Autism Spectrum Disorders. Thirty-six children with Autism Spectrum Disorders and thirty-eight healthy children, from Sfax (a southern area of Tunisia) matched for age and sex, were included in the study. The severity of Autism Spectrum Disorders was evaluated using the childhood autism rating scale. Standard lipid profile (total cholesterol, triglycerides, and high-density lipoprotein-cholesterol), serum glucose, high-sensitive C-reactive protein, and orosomucoid levels were measured utilizing standard techniques; oxysterol levels were m...
Source: Biochimie - Category: Biochemistry Authors: Tags: Biochimie Source Type: research

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Publication date: Available online 21 October 2018Source: Colloids and Surfaces A: Physicochemical and Engineering AspectsAuthor(s): Claudia Zielke, Yi Lu, Lars NilssonAbstractA plethora of studies have shown the ability of cereal dietary fiber to improve intestinal health and to protect the colon from diseases. Lowering of blood cholesterol levels and a reduced risk of coronary heart diseases are just examples for beneficial health effects often directly related to β-glucan from cereal grains. β-Glucan is one of the major components of dietary fiber and is found with highest abundance in oat and barley. Yet, alt...
Source: Colloids and Surfaces A: Physicochemical and Engineering Aspects - Category: Chemistry Source Type: research
Chem. Commun., 2018, Accepted Manuscript DOI: 10.1039/C8CC07921H, CommunicationBikash Sahoo, Takuya Genjo, Michael Bekier II, Sarah N Cox, Andrea Stoddard, Magdalena Ivanova, Kazuma Yasuhara, CA Fierke, Yanzhuang Wang, Ayyalusamy Ramamoorthy Polymethacrylate-copolymer (PMA) encased lipid-nanodiscs (~10 nm) and macro-nanodiscs (>15 nm) are used to study A β1-40 aggregation. We demonstrate that PMA-nanodiscs form a ternary association with Aβ and regulate its aggregation... The content of this RSS Feed (c) The Royal Society of Chemistry
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This study was conducted to recognize the problems of living with a sibling with Autistic Spectrum Disorder (ASD) to improve their quality of life. Method: A total of 30 participants were selected among the 4-to11- year-old ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
Although it is recognized that the prevalence of anxiety is elevated in children with autism spectrum disorder, there has been very limited research exploring such anxiety in school contexts. As a result, there is limited detailed information for teachers ...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Age: Infants and Children Source Type: news
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