Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders.
Plasma oxysterol profiling in children reveals 24-hydroxycholesterol as a potential marker for Autism Spectrum Disorders. Biochimie. 2018 May 03;: Authors: Grayaa S, Zerbinati C, Messedi M, HadjKacem I, Chtourou M, Ben Touhemi D, Naifar M, Ayadi H, Ayedi F, Iuliano L Abstract Cholesterol and its oxygenated metabolites, such as oxysterols, are intensively investigated as potential players in the pathophysiology of brain disorder. Altered oxysterol levels have been described in patients with numerous neuropsychiatric disorders, including Alzheimer's disease, Amyotrophic Lateral Sclerosis, Parkinson's disease, X-linked adrenoleukodystrophy, and Smith-Lemli-Opitz Syndrome. Recent studies have shown that Autism Spectrum Disorders are associated with disruption of cholesterol metabolism. The present study aimed at investigating the profile of oxysterols in plasma and their association with clinical parameters in patients with Autism Spectrum Disorders. Thirty-six children with Autism Spectrum Disorders and thirty-eight healthy children, from Sfax (a southern area of Tunisia) matched for age and sex, were included in the study. The severity of Autism Spectrum Disorders was evaluated using the childhood autism rating scale. Standard lipid profile (total cholesterol, triglycerides, and high-density lipoprotein-cholesterol), serum glucose, high-sensitive C-reactive protein, and orosomucoid levels were measured utilizing standard techniques; oxysterol levels were m...
Conclusion: The Activa PC IPG demonstrates a significantly reduced battery life of 2.1 years, with a median battery life of 4.5 years in comparison to 6.6 years in the Kinetra IPG. Future technology developments should therefore be focused on improving the battery life of the newer IPG systems.Stereotact Funct Neurosurg
(Reuters Health) - Fathers' use of antidepressant medications around the time mothers become pregnant does not increase babies' risk of preterm birth, birth defects, autism or intellectual disability, according to a study in the BMJ.
Fecal microbiota transplantation can be used for the first-line treatment of C difficile, and it might also have an effect on neurologic and autoimmune diseases, such as autism and alopecia areata.Medscape Medical News
Alzheimer's patients older than 65 benefit the most benefit from deep brain stimulation, according to findings from a recent phase II clinical trial.
“As it prepares to turn 70, the NHS is coming towards the worst decade in its existence as far as funding goes,” began the discussion of health and social care. The mover of the motion said that, “services have been repeatedly run down by a government that prefers tax cuts for the wealthy to a well-funded NHS… we now have a permanent winter for our NHS and workloads and stress loads have gone through the roof for many members.” Tracy Holmes, from Sefton local government branch, told delegates about the bad practise in homecare she had witnessed: from visits of just five minutes scheduled...
Condition: Parkinson Disease Interventions: Biological: VY-AADC02; Other: Placebo Sponsor: Voyager Therapeutics Not yet recruiting
Conditions: Alzheimer Disease; Mild Cognitive Impairment Intervention: Diagnostic Test: Pramlintide challenge test Sponsor: Boston University Not yet recruiting
Scientists at Cincinnati Children ’s Hospital have solved the mystery of why a gene already linked to some people with autism is critical to healthy neuronal connections in the developing brain, which offers hope for patients. A study by the researchers at the Avondale hospital indicates that disruption of the gene CHD8 hinders t he production and maintenance of nerve insulation, which harms the brain’s neuronal connections and contributes to white matter damage. Although previous studies showed…
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Nicolas Gigu ère, Samuel Burke Nanni, Louis-Eric Trudeau