Drug resistance in glioblastoma and cytotoxicity of seaweed compounds, alone and in combination with anticancer drugs: A mini review

Conclusion Several natural compounds, existing in seaweeds, such as fucoxanthin and phoroglucinol have shown cytotoxic activity in in vitro and in vivo models acting through different molecular mechanisms, such as antioxidant, antiproliferative, DNA damage/DNA repair, proapoptotic, antiangiogenic and antimetastic. Within the scope of interactions with conventional drugs, there are evidences that some seaweed compounds could be used to potentiate the action of anticancer drugs. However, their effects and mechanisms of action, alone or in combination with anticancer drugs, namely TMZ, in glioblastoma cell, still few explored and require more attention due to the unquestionable high potential of these marine compounds. Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research