Evaluation of dried blood spot sampling for pharmacokinetic research and therapeutic drug monitoring of anti-tuberculosis drugs in children

With an annual incidence over nine million, tuberculosis (TB) is one of the leading public health problems worldwide. In children, the total estimated incidence of tuberculosis in 2015 was about 1 million. Different factors are known to affect TB treatment outcome, including adherence to TB drugs, co-morbidity and drug resistance. In addition, variability in the pharmacokinetics (PK) of first line TB drugs is a major determinant of treatment outcome [1]. From adult studies it is known that low plasma concentrations of TB drugs are related to treatment failure and to acquired TB drug resistance [2 –6].

Source: International Journal of Antimicrobial Agents - May 8, 2018 Category: Drugs & Pharmacology Authors: Lisa C Martial, Jordy Kerkhoff, Nilza Martinez, Mabel Rodr íguez, Rosarito Coronel, Gladys Molinas, Myriam Roman, Roscio Gomez, Sarita Aguirre, Erwin Jongedijk, Justine Huisman, Daan J Touw, Domingo Pérez, Gilberto Chaparro, Felipe Gonzalez, Rob E Aarno Tags: Short Communication Source Type: research