Submandibular function recovery after IMRT in head and neck cancer: A prospective dose modelling study.

CONCLUSION: The submandibular gland function declines after radiotherapy with a nadir at 12 months and there is incomplete recovery over time with continued improvement over 24 months. The TD 50 at 1 year and 2 year was 36 Gy and 44 Gy with a 2-2.5% reduction in the probability of severe xerostomia for every 1 Gy reduction in mean dose.
PMID: 29724411 [PubMed - as supplied by publisher]

Source: Radiotherapy and Oncology : journal of the European Society for Therapeutic Radiology and Oncology - April 30, 2018 Category: Radiology Authors: Murthy V, Lewis S, Kannan S, Khadanga CR, Rangarajan V, Joshi K, Gandhi M, Dey S, Rokde G, Budrukkar A, Gupta T, Laskar S, Agarwal JP Tags: Radiother Oncol Source Type: research