Next Steps for Research on Probiotics and Microbial-Host Keystone Organisms

Could discoveries aboutprobiotics and the microbiome eventually help us to eat healthier, live longer, and even eliminate some chronic  diseases?
Source: NCCAM Featured Content - Category: Complementary Medicine Authors: Source Type: news

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Publication date: Available online 13 December 2018Source: Zoologischer AnzeigerAuthor(s): Nurcan Özyurt Koçakoğlu, Selami Candan, Zekiye SuludereAbstractThe morphology and histology of the female reproductive system of Gerris lacustris water strider (Linnaeus 1758) (Heteroptera: Gerridae) are described using both light and scanning electron microscopy (SEM). Based on histomorphology, the adult female reproductive system of G. lacustris consists of a pair of ovaries, a pair of lateral oviducts, a common oviduct. The ovaries are connected to a genital aperture by oviducts. Each adult ovary is composed of four t...
Source: A Journal of Comparative Zoology - Category: Zoology Source Type: research
Publication date: Available online 13 December 2018Source: Small Ruminant ResearchAuthor(s): Oveas Rafiq Parray, Mohd. Iqbal Yatoo, Muheet Mir, Riyaz Ahmad Bhat, Hamid Ullah Malik, Shah Tauseef Bashir, Suhail Nabi MagrayAbstractContagious caprine pleuroneumonia (CCPP), a highly contagious and severe respiratory disease of goats caused by Mycoplasma capricolum subspecies capripneumonia (Mccp) has not been reported in Pashmina goats of this trans-Himalayan region when there are ample clinico-pathological evidences of the occurrence of this disease. Further analyses of risk factors have not been carried out. Thus in this stud...
Source: Small Ruminant Research - Category: Zoology Source Type: research
yai K Abstract SUMMARYThe tick-borne pathogen Powassan virus is a rare cause of encephalitis in North America and the Russian Far East. The number of documented cases described since the discovery of Powassan virus in 1958 may be 50% of survivors make Powassan virus a medical concern requiring the attention of public health authorities and clinicians. The medical importance of Powassan virus justifies more research on developing specific and effective treatments and prevention and control measures. PMID: 30541872 [PubMed - in process]
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
This article is an American Society for Microbiology (ASM)-sponsored Practical Guidance for Clinical Microbiology (PGCM) document identifying best practices for diagnosis and characterization of viruses that cause acute respiratory infections and replaces the most recent prior version of the ASM-sponsored Cumitech 21 document, Laboratory Diagnosis of Viral Respiratory Disease, published in 1986. The scope of the original document was quite broad, with an emphasis on clinical diagnosis of a wide variety of infectious agents and laboratory focus on antigen detection and viral culture. The new PGCM document is designed to be ...
Source: Clinical Microbiology Reviews - Category: Microbiology Authors: Tags: Clin Microbiol Rev Source Type: research
Abstract The emergence of nanomaterials in industrial processing and consumer products has generated an increased presence of nano-enabled products in the environment and now pose an increased risk of exposure to living organisms. However, assessing the risks of nanomaterials is a challenging task because of a large variety and great variability in their properties. Here, we describe a methodology for assessing toxicity and evaluate potential risks posed by nanomaterials using zebrafish embryos as a model organism. Zebrafish are a well-established organism that has a number of advantages over other biological mode...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Abstract DNA methylation is a process by which methyl groups are added to cytosine or adenine. DNA methylation can change the activity of the DNA molecule without changing the sequence. Methylation of 5-methylcytosine (5mC) is widespread in both eukaryotes and prokaryotes, and it is a very important epigenetic modification event, which can regulate gene activity and influence a number of key processes such as genomic imprinting, cell differentiation, transcriptional regulation, and chromatin remodeling. Profiling DNA methylation across the genome is critical to understanding the influence of methylation in normal ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
This study describes how to use real-time PCR to evaluate the effects of nanomaterials on mitochondrial genome transcription in male reproductive cells. PMID: 30547462 [PubMed - in process]
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Abstract Mitochondria hold a critical role in cell metabolism and homeostasis. Mitochondrial injury plays central part in deciding cell fate especially in programmed cell death pathways. Various nanomaterials lead to different cell death modalities by inducing mitochondrial injury. Mitochondrial injury is manifested as multiple biochemical events ranging from altered energy production, mitochondrial outer membrane permeability, release of pro-apoptotic BCl-2 family proteins, loss of mitochondrial inner membrane potential, mitochondrial swelling, and disruption of mitochondrial structure leading to eventual lysis o...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
ase A Abstract Genotoxicity is associated with serious health effects and includes different types of DNA lesions, gene mutations, structural chromosome aberrations involving breakage and/or rearrangements of chromosomes (referred to as clastogenicity) and numerical chromosome aberrations (referred to as aneuploidy). Assessing the potential genotoxic properties of chemicals, including nanomaterials (NMs), is a key element in regulatory safety assessment. State-of-the-art genotoxicity testing includes a battery of assays covering gene mutations, structural and numerical chromosome aberrations. Typically various in ...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
Abstract Increasing evidence demonstrates that a substantial number of chemicals including nanoparticles have potential toxic effects on human and wildlife reproductive health. Ovarian granulosa cells (GCs), the functional unit of the ovary, play a pivotal role in the regulation of ovarian reproductive health in females. They are considered to be the main target by the chemicals at all stages of their development. It has been reported that nanoparticles induced toxicity of GCs by interfering with cell cycle. Some basic methods for evaluation of GCs with exposure to nanoparticles are described in this chapter inclu...
Source: Mol Biol Cell - Category: Molecular Biology Authors: Tags: Methods Mol Biol Source Type: research
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