Comprehensive expression analysis of TNF-related apoptosis-inducing ligand and its receptors in colorectal cancer: Correlation with MAPK alterations and clinicopathological associations.

In conclusion, simultaneous analysis of TRAIL pathway membrane components, pointed towards a significant deregulation of mRNA expression in colorectal tumours. Death receptor overexpression was an indicator of a less aggressive phenotype. The multiple expression patterns of TRAIL pathway components in colorectal tumours underscore the importance of patient selection in order to achieve maximum efficiency with TRAIL targeted therapy. PMID: 29731264 [PubMed - as supplied by publisher]

https://www.ncbi.nlm.nih.gov/pubmed/29731264?dopt=Abstract

Source: Pathology, Research and Practice - May 1, 2018 Category: Pathology Authors: Tsikalakis S, Chatziandreou I, Michalopoulos NV, Theodoropoulos GE, Sakellariou S, Korkolopoulou P, Patsouris E, Saetta AA Tags: Pathol Res Pract Source Type: research