Some Antipsychotics in Pregnancy May Up Gestational Diabetes Risk

(MedPage Today) -- Elevated risk seen with continuing olanzapine, quetiapine
Source: MedPage Today Cardiovascular - Category: Cardiology Source Type: news

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Clin Mol Hepatol. 2021 Sep 17. doi: 10.3350/cmh.2021.0205. Online ahead of print.ABSTRACTBACKGROUND AND AIMS: Maternal and fetal outcomes in pregnant patients with NAFLD have been largely unexplored. To determine the level of evidence associated with both maternal and fetal outcomes in pregnant women with NAFLD.METHOD: We conducted a comprehensive literature search. The studies included pregnant patients with a previous, current or subsequent diagnosis of NAFLD. We used a random-effects model using odds ratios (OR) with 95% confidence intervals (CI).RESULTS: Twenty two studies, with 13641 female NAFLD patients were reviewe...
Source: Clinical and molecular hepatology - Category: Gastroenterology Authors: Source Type: research
AbstractGestational diabetes mellitus (GDM) is the most common form of dysglycaemia during pregnancy. GDM is defined as hyperglycemia diagnosed for the first time during pregnancy, most commonly during the second or third trimester. GDM can be harmful to both the mother and the offspring. Complications to fetuses include excessive birthweight and preterm birth, while women with GDM are more susceptible to gestational hypertension, pre-eclampsia, and postpartum abnormal glucose intolerance (pAGT).
Source: Journal of Diabetes Investigation - Category: Endocrinology Authors: Tags: UPDATE Source Type: research
BJOG. 2021 Sep 16. doi: 10.1111/1471-0528.16922. Online ahead of print.ABSTRACTOBJECTIVE: To evaluate the association between maternal fructosamine levels at the time of delivery and stillbirth.DESIGN: Secondary analysis of a case-control study.SETTINGS: Multicenter study of five geographic catchment areas in the United States (U.S).POPULATION OR SAMPLE: All singleton stillbirths with known diabetes status and fructosamine measurement and representative live birth controls.MAIN OUTCOME MEASURES: Fructosamine levels in stillbirths and live births among groups were adjusted for potential confounders including diabetes. Optim...
Source: BJOG : An International Journal of Obstetrics and Gynaecology - Category: OBGYN Authors: Source Type: research
CONCLUSIONS: Neonatal factors, particularly delivery mode, were associated with many cord blood metabolite differences, including those implicated in later risk of cardiometabolic disease. Associations between GDM and higher offspring ketone levels at birth are consistent with maternal ketosis in diabetic pregnancies. Further work is needed to determine whether these neonatal metabolome differences associate with later health outcomes.IMPACT: Variations in blood metabolomic profile have been linked to health status in adults and children, but corresponding data in neonates are scarce. We report evidence that pregnancy comp...
Source: Pediatric Research - Category: Pediatrics Authors: Source Type: research
There is a high burden of gestational diabetes (GDM) and type 2 diabetes in pregnancy for Aboriginal and Torres Strait Islander women. Postpartum diabetes programs have the potential to prevent recurrent GDM a...
Source: BMC Pregnancy and Childbirth - Category: OBGYN Authors: Tags: Research Source Type: research
Source: International Journal of General Medicine - Category: General Medicine Tags: International Journal of General Medicine Source Type: research
Eur J Endocrinol. 2021 Sep 1:EJE-21-0635.R1. doi: 10.1530/EJE-21-0635. Online ahead of print.ABSTRACTAIMS: To assess whether in women with gestational diabetes mellitus (GDM), postpartum plasma glycated CD59 (pGCD59) levels predict conversion to glucose intolerance diagnosed with an oral glucose tolerance test (OGTT).METHODS: Blood levels of pGCD59 were measured in a case-control study of 105 women with GDM who underwent a 75g OGTT three months postpartum. The 35 postpartum glucose intolerant cases were individually matched for age, BMI, ethnic origin and parity with 70 women with GDM but normal postpartum OGTT (controls)....
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Source Type: research
Mol Aspects Med. 2021 Sep 11:101023. doi: 10.1016/j.mam.2021.101023. Online ahead of print.ABSTRACTTobacco smoking is an important public health issue recognized by the world health organization as one of the most serious, preventable risk factors for developing a series of pregnancy pathologies. Maternal smoking is positively associated with intrauterine growth restriction (IUGR) and gestational diabetes (GDM), but negatively associated with preeclampsia (PE). In this review, we examine epidemiological, clinical and laboratory studies of smoking effects on immunoregulation during pregnancy, trophoblast function, and place...
Source: Molecular Medicine - Category: Molecular Biology Authors: Source Type: research
Eur J Endocrinol. 2021 Sep 1:EJE-21-0635.R1. doi: 10.1530/EJE-21-0635. Online ahead of print.ABSTRACTAIMS: To assess whether in women with gestational diabetes mellitus (GDM), postpartum plasma glycated CD59 (pGCD59) levels predict conversion to glucose intolerance diagnosed with an oral glucose tolerance test (OGTT).METHODS: Blood levels of pGCD59 were measured in a case-control study of 105 women with GDM who underwent a 75g OGTT three months postpartum. The 35 postpartum glucose intolerant cases were individually matched for age, BMI, ethnic origin and parity with 70 women with GDM but normal postpartum OGTT (controls)....
Source: European Journal of Endocrinology - Category: Endocrinology Authors: Source Type: research
One of the most prevalent pregnancy-related complications is Gestational Diabetes Mellitus (GDM) [1]. It is defined as inadequate insulin secretory response and hyperglycemia in pregnant women without pre-existing diabetes [1]. The prevalence of GDM varies across countries. In high-income countries, it is reported to be between 1.7 –11.6% [2], while in East and Southeast Asia, this rate is estimated to be 10.1% (6.5%–15.7%) [3]. Age, high body mass index (BMI), strong family history of diabetes in first and second degree relatives, and previous history of gestational diabetes are among the most important risk f...
Source: Primary Care Diabetes - Category: Primary Care Authors: Tags: Review Source Type: research
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