Proteomic Analyses of Human Regulatory T Cells Reveal Adaptations in Signaling Pathways that Protect Cellular Identity

Using high-resolution mass spectrometry and transcriptomics, Cuadrado et  al. provide a molecular characterization of regulatory and conventional CD4+ T cell subsets, yielding markers to distinguish cells with different properties and insights into mechanisms that prevent regulatory T cells from exhibiting undesirable functional activities of the related but functiona lly antithetical conventional T cells.

Source: Immunity - May 8, 2018 Category: Allergy & Immunology Authors: Eloy Cuadrado, Maartje van den Biggelaar, Sander de Kivit, Yi-yen Chen, Manon Slot, Ihsane Doubal, Alexander Meijer, Rene A.W. van Lier, Jannie Borst, Derk Amsen Tags: Resource Source Type: research