AllergoOncology: Generating a canine anti-cancer IgE against the epidermal growth factor receptor (EGFR)

Anti-cancer immunotherapies currently rely on IgG antibodies. In line with the AllergoOncology concept we provide evidence that tumor-specific IgE, alone or combined with IgG, may be superior to IgG treatment alone. The novel can225IgE- λ was made for future studies in dogs as translational model patients.

Source: Journal of Allergy and Clinical Immunology - May 7, 2018 Category: Allergy & Immunology Authors: Judit Fazekas-Singer, Josef Singer, Kristina M. Ilieva, Miroslawa Matz, Ina Herrmann, Edzard Spillner, Sophia N. Karagiannis, Erika Jensen-Jarolim Source Type: research