CT perfusion in non-small cell lung cancers for assessing treatment response, monitoring treatment and predicting prognosis

Conclusions Tumours with higher baseline BF and PS respond well to chemo-radiation. Changes in the PS values can predict the development of metastasis and hence, the long term outcome.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research

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ConclusionThe incorporation of functional imaging for radiotherapy planning in non-small cell lung cancer is feasible and appears to be beneficial in preserving a  functional lung in non-small cell lung cancer.
Source: Strahlentherapie und Onkologie - Category: Cancer & Oncology Source Type: research
CONCLUSION: A 10-20 Gy radiation dose to anatomic or perfused lung results in decline in FEV1. A fractional anatomic volume of>5% receiving>50 Gy influences development of RALI. ADVANCES IN KNOWLEDGE: Extent of low-dose radiation to normal lung influences functional respiratory decline. PMID: 31287737 [PubMed - as supplied by publisher]
Source: The British Journal of Radiology - Category: Radiology Authors: Tags: Br J Radiol Source Type: research
This study investigated the noninvasive assessment of tumor vascularization with clinical F-18-fluorodeoxyglucose positron emission tomography/computed tomography and contrast-enhanced computed tomography ([18F]FDG-PET/CT and CE-CT) in experimental human xenograft tumors with modifiable vascularization and compared results to histology. Tumor xenografts with modifiable vascularization were established in 71 athymic nude rats by subcutaneous transplantation of human non-small-cell lung cancer (NSCLC) cells. Four different groups were transplanted with two different tumor cell lines (either A549 or H1299) alone or tumors co-...
Source: EJNMMI Research - Category: Radiology Source Type: research
Abstract PURPOSE: To directly compare the utility for therapeutic outcome prediction of dynamic first-pass contrast-enhanced (CE)-perfusion area-detector computed tomography (ADCT), MR imaging assessed with the same mathematical method and 2-[fluorine-18]-fluoro-2-deoxy-d-glucose-positron emission tomography combined with CT (PET/CT) for non-small cell lung cancer (NSCLC) patients treated with chemoradiotherapy. MATERIALS AND METHODS: Forty-three consecutive stage IIIB NSCLC patients, consisting of 25 males (mean age ± standard deviation: 66.6 ± 8.7 years) and 18 females (66.4 ± 8.2 years...
Source: Magnetic Resonance in Medical Sciences : MRMS - Category: Radiology Authors: Tags: Magn Reson Med Sci Source Type: research
ConclusionsTime-courses of whole tumor FMISO uptake by advanced stage NSCLC are described best by an irreversible three-tissue compartment model. TheK1 values obtained from fits of the irreversible three-tissue model correlated strongly with independent blood flow measurements obtained from perfusion CT (r = 0.81).
Source: EJNMMI Research - Category: Radiology Source Type: research
ConclusionsTumours with higher baseline BF and PS respond well to chemo-radiation. Changes in the PS values can predict the development of metastasis and hence, the long term outcome.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research
Publication date: Available online 1 March 2018Source: Practical Radiation OncologyAuthor(s): Soumyajit Roy, Iulian Badragan, Sheikh Nisar Ahmed, Michael Sia, Jorawur Singh, Gaurav BahlAbstractPurposeThe purpose of this article was to generate an algorithm to calculate radiobiological endpoints and composite indices and use them to compare volumetric modulated arc therapy (VMAT) and 3-dimensional conformal radiation therapy (3D-CRT) techniques in patients with locally advanced non-small cell lung cancer.Methods and materialsThe study included 25 patients with locally advanced non-small cell lung cancer treated with 3D-CRT ...
Source: Practical Radiation Oncology - Category: Cancer & Oncology Source Type: research
ConclusionsTumours with higher baseline BF and PS respond well to chemo-radiation. Changes in the PS values can predict the development of metastasis and hence, the long term outcome.
Source: The Egyptian Journal of Radiology and Nuclear Medicine - Category: Nuclear Medicine Source Type: research
1157Objectives: 1. Comparison between PET/CT and PET/MRI in detecting distant metastases of lung cancer 2. Review of the potential advantages of PET/MRI compared with PET/CT in assessment of patients with lung cancer 3. Highlight the limitations of PET/MRI in lung cancer assessment Abstract: Lung cancer is one of the most common cancers in the world, causing high morbidity and mortality, and is under active study through use of positron emission tomography/magnetic resonance imaging (PET/MRI). Lung cancers are divided into non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC) subtypes. The treatment and prog...
Source: Journal of Nuclear Medicine - Category: Nuclear Medicine Authors: Tags: Educational Exhibits Source Type: research
ConclusionThe present study suggests that [18F]FLT might be a perfusion-independent PET tracer for measuring tumour response as parametric changes in [18F]FLT uptake occurred independent from changes in perfusion.Trial registrationNederlands Trial Register (NTR),NTR3557. Registered 2 August 2012
Source: EJNMMI Research - Category: Radiology Source Type: research
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