Descemet Membrane Endothelial Keratoplasty Learning Curve for Graft Preparation in an Eye Bank Using 645 Donor Corneas

Conclusions: There is a learning curve for DMEK graft preparation. ECL and tissue wastage can be reduced with practice and skills. However, each operator may be limited to his or her own learning capability.
Source: Cornea - Category: Opthalmology Tags: Basic Investigation Source Type: research

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Authors: Berger EA Abstract Keratitis is a sight-threatening inflammatory condition of the cornea that can be caused by both infectious and non-infectious agents. Physical or chemical trauma are typically related to non-infectious keratitis, which may then become secondarily infected or remain non-infected. Etiology of infectious keratitis is most often associated with bacteria; but viruses, fungi, and parasites are common causative pathogens as well. As a global concern, common risk factors include: systemic immunosuppression (secondary to malnutrition, alcoholism, diabetes, steroid use), previous corneal surgery ...
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research
In this study, researchers studied 438,952 participants in the UK Biobank, who had a total of 24,980 major coronary events - defined as the first occurrence of non-fatal heart attack, ischaemic stroke, or death due to coronary heart disease. They used an approach called Mendelian randomisation, which uses naturally occurring genetic differences to randomly divide the participants into groups, mimicking the effects of running a clinical trial. People with genes associated with lower blood pressure, lower LDL cholesterol, and a combination of both were put into different groups, and compared against those without thes...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Purpose: To determine whether donor diabetes mellitus (DM) severity is associated with differences in endothelial cell density (ECD) and surgically unsuitable tissue. Methods: Raw data were obtained from Saving Sight Eye Bank (Kansas City, MO) including 10,454 donated eyes from 5346 eligible donors from July 2014 through May 2017. Donors were grouped into 5 categories by their insulin use and the presence of microvascular end-organ complications. The categories were non-DM (NDM), noninsulin-dependent DM without complications (NIDDMnc), noninsulin-dependent DM with complication (NIDDMc), insulin-dependent DM without co...
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Conclusions: Epithelial ingrowth may occur after a corneal endothelium transplant. There have been multiple reports of epithelial ingrowth after Descemet stripping automated endothelial keratoplasty, but this particular case report suggests that epithelial ingrowth may also occur after DMEK. In this case, PK solved the complication.
Source: Cornea - Category: Opthalmology Tags: Case Report Source Type: research
Purpose: To investigate factors associated with cystoid macular edema (CME) after Descemet membrane endothelial keratoplasty (DMEK) in Asian eyes. Methods: In this retrospective, interventional, consecutive case series, 77 eyes of 65 patients who underwent DMEK were evaluated; in 53 eyes, cataract surgery was performed 1 month before DMEK (staged DMEK), and 24 eyes underwent DMEK alone (simple DMEK). Central retinal thickness, incidence of CME, postoperative best-corrected visual acuity, central corneal thickness, and corneal endothelial cell density were assessed at 1, 3, and 6 months after surgery. Multiple regressi...
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
AbstractAims/hypothesisThe study aimed to assess the impact on neuropathy of simultaneous pancreas and kidney transplantation (SPK) in individuals with type 1 diabetes.MethodsThis longitudinal observational study examined neuropathic symptoms, deficits, quantitative sensory testing, neurophysiology, corneal confocal microscopy and skin biopsy results in 32 healthy (non-diabetic) control participants, 29 individuals with type 1 diabetes and severe diabetic peripheral neuropathy [DPN] and 36 individuals with type 1 diabetes after SPK.ResultsFollowing SPK, HbA1c, eGFR, triacylglycerols and HDL improved significantly (allp 
Source: Diabetologia - Category: Endocrinology Source Type: research
AbstractPurpose of ReviewTo review the clinical factors for endothelial cell density (ECD) loss and graft failure after corneal transplantation.Recent FindingsReduction of ECD after corneal transplantation is associated with various clinical factors, such as the presence of glaucoma, graft diameter, donor age, donor diabetes, and donor gender. Recently, we reported the severe preexisting iris damage was one of the clinical factors for rapid ECD loss and graft failure. We also showed that preexisting iris damage causes chronic elevation of cytokine levels in the aqueous humor (AqH). Furthermore, the higher preoperative leve...
Source: Current Ophthalmology Reports - Category: Opthalmology Source Type: research
I met ophthalmologist and corneal specialist Dr. Peter Polack while speaking in Ocala, Florida. He told me that, by having his patients with dry eye—which has increased dramatically over the last 20 years—remove all wheat and grains, he is seeing this condition reverse within weeks, along with all the other health benefits. Unlike other ophthalmologists, who virtually have nothing to do with diet and therefore prescribe the costly drugs Restasis and Xiidra (each cost $500-$550 per month), Dr. Polack rarely has to resort to use of these awful agents. Here Dr. Polack speaks about his phenomenal experience. More a...
Source: Wheat Belly Blog - Category: Cardiology Authors: Tags: News & Updates autoimmune dry eye gluten-free grain-free grains Inflammation restasis undoctored wheat belly xiidra Source Type: blogs
Conclusions: Lower ECD was associated with DM. Lower ECD was not associated with metformin use except in a subgroup of patients with glaucoma, in which subgroup analysis showed lower ECD. The differences in ECD observed were small and unlikely to affect the suitability for transplantation of donor corneas.
Source: Cornea - Category: Opthalmology Tags: Clinical Science Source Type: research
Abstract Here, we present, to the best of our knowledge, the first case of Werner syndrome with corneal blindness due to bilateral primary bullous keratopathy. Werner syndrome is a rare autosomal recessive disorder characterized by features of premature aging, insulin-dependent diabetes mellitus, osteoporosis, atherosclerosis, hypergonadotrophic hypogonadism, hypertriglyceridemia, scleroderma-like skin changes, and sarcomas. Among ocular manifestations, cataracts, cystoid macular edema, and retinal detachment have been reported. Because these patients show features of premature aging, they have decreased corneal e...
Source: Experimental and Clinical Transplantation : official journal of the Middle East Society for Organ Transplantation - Category: Transplant Surgery Authors: Tags: Exp Clin Transplant Source Type: research
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