Mouse models of peripheral metabolic disease

Metabolic disease risk is driven by defects in the function of cells that regulate energy homeostasis, as well as altered communication between the different tissues or organs that these cells occupy. Thus, it is desirable to use model organisms to understand the contribution of different cells, tissues and organs to metabolism. Mice are widely used for metabolic research, since well-characterised mouse strains (in terms of their genotype and phenotype) allow comparative studies and human disease modelling.

Source: Best Practice and Research. Clinical Endocrinology and Metabolism - March 31, 2018 Category: Endocrinology Authors: Gabriela da Silva Xavier, David J. Hodson Tags: 7 Source Type: research