Pharmacotherapy for the treatment of depression in patients with alzheimer's disease: a treatment-resistant depressive disorder.

Pharmacotherapy for the treatment of depression in patients with alzheimer's disease: a treatment-resistant depressive disorder. Expert Opin Pharmacother. 2018 May 04;:1-20 Authors: Lozupone M, La Montagna M, D'Urso F, Piccininni C, Sardone R, Dibello V, Giannelli G, Solfrizzi V, Greco A, Daniele A, Quaranta N, Seripa D, Bellomo A, Logroscino G, Panza F Abstract INTRODUCTION: Pharmacotherapy for the treatment of depressive disorders in Alzheimer's Disease (AD) represents a clinical challenge. pharmacological options are often attempted after a period of watchful waiting (8-12 weeks). monoaminergic antidepressant drugs have shown only modest or null clinical benefits, maybe because the etiology of depressive symptoms in ad patients is fundamentally different from that of nondemented subjects. Areas covered: The following article looks at the selective serotonin reuptake inhibitor sertraline, which is one of the most frequently studied antidepressant medications in randomized controlled trials (RCTs). It also discusses many other pharmacological approaches that have proven to be inadequate (antipsychotics, acetylcholinesterase inhibitors, anticonvulsants, hormone replacement therapy) and new drug classes (mainly affecting glutamate transmission) that are being studied for treating depression in AD. It also gives discussion to the phase II RCT on the alternative drug S47445 and the potential effect on cognition of the multimodal antidepressant vortioxet...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

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Conclusions—Genetic variants within the VCAN gene may play a role in the mechanisms underlying microstructural integrity of the white matter in the brain measured as FA and MD. Mechanisms underlying white matter alterations are shared with cerebrovascular disease, and inherited differences in white matter microstructure impact on Alzheimer disease and major depressive disorder.
Source: Stroke - Category: Neurology Authors: Tags: Genetic, Association Studies, Magnetic Resonance Imaging (MRI), Cerebrovascular Disease/Stroke Original Contributions Source Type: research
While a link has previously been shown between the APOE epsilon 4 genetic variant and neuropathology, new research suggests it also elevates risk for psychiatric symptoms after TBI.Medscape Medical News
Source: Medscape Medical News Headlines - Category: Consumer Health News Tags: Neurology & Neurosurgery News Source Type: news
Conclusion Deficits in mitochondrial function, dynamics, and antioxidant capabilities putatively mediated through sub-optimal AMPK/SIRT/PGC-1α signaling, are involved in the development of early sub-clinical neurodegeneration in the cortex under diabetic conditions.
Source: Molecular and Cellular Neuroscience - Category: Neuroscience Source Type: research
Alzheimer’s disease and other illnesses that cause dementia are devastating, not only for those affected but also for their friends and family. For most forms of dementia, there is no highly effective treatment. For example, available treatments for Alzheimer’s disease may slow the deterioration a bit, but they don’t reverse the condition. In fact, for most people taking medications for dementia, it may be difficult to know if the treatment is working at all. Experts predict that dementia will become much more common in the coming years. We badly need a better understanding of the cause of these condition...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Alzheimer's Disease Brain and cognitive health Drugs and Supplements Memory Source Type: blogs
aki Nanogels are drug delivery systems that can bypass the blood-brain barrier and deliver drugs to the desired site when administered intranasally. They have been used as a drug delivery platform for the management of brain diseases such as Alzheimer disease, migraine, schizophrenia and depression. nanogels have also been developed as vaccine carriers for the protection of bacterial infections such as influenza, meningitis, pneumonia and as veterinary vaccine carriers for the protection of animals from encephalomyelitis and mouth to foot disease. It has been developed as vaccine carriers for the prevention of lifestyl...
Source: Molecules - Category: Chemistry Authors: Tags: Review Source Type: research
Authors: de Oliveira RW, Oliveira CL, Guimarães FS, Campos AC Abstract Cannabinoid signalling modulates several aspects of brain function, including the generation and survival of neurons during embryonic and adult periods. The present review intended to summarise evidence supporting a role for the endocannabinoid system on the control of neurogenesis and neurogenesis-dependent functions. Studies reporting participation of cannabinoids on the regulation of any step of neurogenesis and the effects of cannabinoid compounds on animal models possessing neurogenesis-dependent features were selected from Medline. ...
Source: Acta Neuropsychiatrica - Category: Psychiatry Tags: Acta Neuropsychiatr Source Type: research
"The ordinary acts we practice every day at home are of more importance to the soul than their simplicity might suggest." -- Thomas MooreAlzheimer's DementiaBy Bob DeMarcoAlzheimer's Reading Room1.The Metamorphosis of This Alzheimer's CaregiverThe more I learned the more I wanted to know. I learned a great deal about Alzheimer's disease and dementia--including the science. It helped me understand a very mystifying disease. It helped me to put a frame around something that is difficult if not impossible to describe.________________________________________2.Communication in Alzheimer's WorldLearning how to communic...
Source: Alzheimer's Reading Room, The - Category: Neurology Tags: alzheimer's care family caregiving help alzheimer's help with dementia help with dementia care memory care senior care resources Source Type: blogs
Depressive states have been linked to the development of neurodegenerative disorders such as Alzheimer's disease (AD). Indeed, depression is a common feature in early AD representing a clinical manifestation of this disease before cognitive decline (Visser  et al., 2000). Depression has been indicated as a risk factor for AD and depressed subjects, mild cognitive impaired, show more than twice the risk of developing AD-type dementia than non-depressed (Modrego and Ferrandez, 2004). In this regard, neuropsychiatric symptoms have been reported as pr odromal symptoms of dementia deriving from neurobiologic...
Source: Journal of Affective Disorders - Category: Neurology Authors: Source Type: research
Conclusions: In this review we will provide animal and human research data on the current clinical neurological uses for CBD individually and in combination with Δ9-THC. We will emphasize the neuroprotective, antiinflammatory, and immunomodulatory benefits of phytocannabinoids and their applications in various clinical syndromes. PMID: 29770251 [PubMed]
Source: Surgical Neurology International - Category: Neurosurgery Tags: Surg Neurol Int Source Type: research
Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease, Published online: 16 May 2018; doi:10.1038/s41386-018-0090-0Multivariate meta-analyses of mitochondrial complex I and IV in major depressive disorder, bipolar disorder, schizophrenia, Alzheimer disease, and Parkinson disease
Source: Neuropsychopharmacology - Category: Neurology Authors: Source Type: research
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