Pharmacotherapy for the treatment of depression in patients with alzheimer's disease: a treatment-resistant depressive disorder.

Pharmacotherapy for the treatment of depression in patients with alzheimer's disease: a treatment-resistant depressive disorder. Expert Opin Pharmacother. 2018 May 04;:1-20 Authors: Lozupone M, La Montagna M, D'Urso F, Piccininni C, Sardone R, Dibello V, Giannelli G, Solfrizzi V, Greco A, Daniele A, Quaranta N, Seripa D, Bellomo A, Logroscino G, Panza F Abstract INTRODUCTION: Pharmacotherapy for the treatment of depressive disorders in Alzheimer's Disease (AD) represents a clinical challenge. pharmacological options are often attempted after a period of watchful waiting (8-12 weeks). monoaminergic antidepressant drugs have shown only modest or null clinical benefits, maybe because the etiology of depressive symptoms in ad patients is fundamentally different from that of nondemented subjects. Areas covered: The following article looks at the selective serotonin reuptake inhibitor sertraline, which is one of the most frequently studied antidepressant medications in randomized controlled trials (RCTs). It also discusses many other pharmacological approaches that have proven to be inadequate (antipsychotics, acetylcholinesterase inhibitors, anticonvulsants, hormone replacement therapy) and new drug classes (mainly affecting glutamate transmission) that are being studied for treating depression in AD. It also gives discussion to the phase II RCT on the alternative drug S47445 and the potential effect on cognition of the multimodal antidepressant vortioxet...
Source: Expert Opinion on Pharmacotherapy - Category: Drugs & Pharmacology Tags: Expert Opin Pharmacother Source Type: research

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Authors: Konstantakopoulos G Abstract There is now general agreement that lack of insight is not merely a fundamental aspect of delusions and hallucinations, or just a symptom of psychotic disorders but rather a multi-dimensional construct. Several different components of insight have been proposed and empirically examined during the last three decades, such as the ability to recognize that one has a mental illness, the capacity to relabel unusual mental events as pathological, the specific attribution of one's symptoms to having a mental illness, awareness of illness' consequences, and compliance with treatment.1 ...
Source: Psychiatriki - Category: Psychiatry Tags: Psychiatriki Source Type: research
This report presents the most recent nationally representative percentages of adult day services centers (ADSCs) with hospitalizations and chronic conditions by service provision. Service provision may further one or two of the primary goals of adult day services: to reduce the risk of hospitalizations and readmissions, and manage chronic conditions among their participants. Methods-Estimates are from the 2016 Adult Day Services Center survey in the biennial National Study of Long-Term Care Providers conducted by the National Center for Health Statistics. Service provision was measured using scales that included five types...
Source: National health statistics reports - Category: American Health Tags: Natl Health Stat Report Source Type: research
“Grow old along with me! The best is yet to be.” – Robert Browning Older adults should be enjoying their so-called “golden years,” yet too many are beset with mental health issues that, in addition to other medical conditions they may have, contribute to a decline in their mental health. There is hope to help counter this, however, and new research points to innovative, as well as common sense, approaches on how to improve the mental health of older adults. Learn How to Cope with Anger Research from the American Psychological Association shows that anger is more harmful to the health of older ...
Source: World of Psychology - Category: Psychiatry & Psychology Authors: Tags: Aging Mental Health and Wellness Alzheimer's disease Dementia Elderly Source Type: blogs
Conclusions: NT analysis results showed that HAL and HAR selectively affect AChE in vivo. HAL and HAR may be highly and suitably developed for the treatment of Alzheimer's disease.Graphical abstract
Source: Phytomedicine - Category: Drugs & Pharmacology Source Type: research
ten H Abstract OBJECTIVES: To compare quality of life (QOL) of family carers of persons with young- (YOD) to late-onset dementia (LOD). METHODS: This was a cross-sectional comparison of 88 carers of persons with YOD and 100 carers of persons with LOD. The Quality of Life - Alzheimer's Disease questionnaire (QOL-AD) was used to measure QOL of both carers and persons with dementia. Depressive symptoms were measured by the Geriatric Depression Scale (GDS) for carers and the Cornell Scale for Depression in Dementia for persons with dementia. Care burden was measured by the Relatives' Stress Scale. Activities of D...
Source: Aging and Mental Health - Category: Geriatrics Authors: Tags: Aging Ment Health Source Type: research
Discussion: Our data support the role ofCOMT, and particularly of rs4680, in the pathogenesis of AD. Furthermore, theSIRT1 gene seems to modulate depressive symptomatology in the AD population.Neuropsychobiology
Source: Neuropsychobiology - Category: Psychiatry & Psychology Source Type: research
The prevalence of depression is dramatically increased and it has been esteemed that over 300 million people suffer from depression all over the world. Depression is highly comorbid with many central and peripheral disorders. In this regard, depressive states have been associated with the development of neurological disorders such as Alzheimer’s disease (AD). Accordingly, depression is a risk factor for AD and depressive symptomatology is common in pre-clinical AD representing an early manifestation of this disease. Neuropsychiatric symptoms may represent prodromal symptoms of dementia deriving from neurobiological c...
Source: Frontiers in Pharmacology - Category: Drugs & Pharmacology Source Type: research
The links between late life depression, cerebrovascular disease (CVD) and Alzheimer's disease (AD) are complicated and multidirectional. The vascular depression hypothesis states that cerebrovascular disease (CVD) can predispose, precipitate and perpetuate late-life depression (LLD), and patients with LLD have higher rates of white matter hyperintensities (WMH) and frontal-executive cognitive dysfunction. Damage to key fronto-subcortical white matter tracts is thought to produce the affective, cognitive and behavioral symptoms seen in LLD.
Source: The American Journal of Geriatric Psychiatry - Category: Geriatrics Authors: Tags: Invited Perspective Source Type: research
CONCLUSION: Because of the exploratory nature of the analyses and the small sample sizes for subgroup analysis there is the need for caution in interpreting these data. Replication of the potential effects of mirtazapine in the subgroup of those with depression in dementia with "psychological" symptoms would be valuable. These data should not change clinical practice, but future trials should consider stratifying types of depression in dementia in secondary analyses. PMID: 31084994 [PubMed - as supplied by publisher]
Source: The American Journal of Geriatric Psychiatry - Category: Psychiatry Tags: Am J Geriatr Psychiatry Source Type: research
Though emotions are often fleeting, they can have a lasting impact on your health. Stress, for example, may heighten the risk of both chronic and acute health conditions, while happiness can improve wellbeing. Now, a small new study published in the journal Psychology and Aging suggests that anger, far more than sadness, is linked to negative health effects in older people, potentially by contributing to inflammation and chronic disease. The new research was borne from a theory developed by two of the study’s co-authors, psychologists Carsten Wrosch and Ute Kunzmann. The theory posits that all emotions — even ...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized Mental Health/Psychology Source Type: news
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