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How Imams, Royalty and Family Celebrations are Wiping Out Polio in Nigeria

Ramlatu Musaa never met the Emir of Kano State in northern Nigeria. Of course, Ramlatu Musaa hasn’t met a lot of people. She’s only about a week old, born in Kano on April 29, 2018, and yet in some ways, the Emir may have helped saved her life. Two years ago, the polio vaccine was available in Nigeria, but it was still frequently rejected by families. Stray rumors continued to circulate that it was unsafe, able to sicken children and render them infertile. So before one of that year’s national vaccination campaigns began, the Emir—a hereditary leader descended from a ruling family—appeared at a public ceremony and called for a vial of polio vaccine to be brought to the stage. With the audience watching, he broke its seal and drank down its entire contents. And with that, vaccine resistance in Nigeria retreated one more step. Ramlatu just got her own, much smaller, two-drop dose of the vaccine, the first of eight polio vaccinations she will receive by the time she is nine years old. As it happens, the seven-days-old mark, which immunological science says is the time that the first vaccine dose should be administered, is also when Nigerian tradition says a baby’s naming ceremony should be held. So for Ramlatu, as for many Nigerian newborns, the two occasions were combined. Her celebration and vaccination took place in a small courtyard in a crowded Kano neighborhood, and the event was packed with mothers and children, along with a few repre...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime public health Source Type: news

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Vaccine responses vary by geographic location. We have previously described how HIV-associated inflammation leads to fibrosis of secondary lymph nodes (LNs) and T cell depletion. We hypothesized that other infections may cause LN inflammation and fibrosis, in a process similar to that seen in HIV infection, which may lead to T cell depletion and affect vaccine responses. We studied LNs of individuals from Kampala, Uganda, before and after yellow fever vaccination (YFV) and found fibrosis in LNs that was similar to that seen in HIV infection. We found blunted antibody responses to YFV that correlated to the amount of LN fib...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
There is marked variability in vaccine efficacy among global populations. In particular, individuals in low- to middle-income countries have been shown to be less responsive to vaccines than those from developed nations. Several factors, including endemic infections, nutrition, genetics, and gut microbiome composition, have been proposed to underlie discrepancies in vaccine response. In this issue of the JCI, Kityo et al. evaluated response to yellow fever virus vaccine, inflammation, and lymphatic tissue architecture and fibrosis in three cohorts: two from the U.S. and one from Uganda. Compared with the U.S. subjects, the...
Source: Journal of Clinical Investigation - Category: Biomedical Science Authors: Source Type: research
(Digestive Disease Week) Combining a DNA vaccine, which boosts the body's immune response against tumors, with an antibody that blocks the body's natural defense against the potency of the DNA vaccine, may lead to the development of an effective treatment for late stage colorectal cancer, when a cure is not often possible. Preliminary research leading up to this trial will be presented at Digestive Disease Week ® 2018.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news
Contributors : Eduardo Ontoria ; Yasmina E Hernandez-Santana ; Ana C Gonzalez-Garc ía ; Manuel C López ; Basilio Valladares ; Emma CarmeloSeries Type : Expression profiling by RT-PCROrganism : Mus musculusLeishmania spp. is a protozoan parasite that affects millions of people around the world. At present, there is no effective vaccine to prevent leishmaniases in humans. A major limitation in vaccine development is the lack of precise understanding of the particular immunological mechanisms that allow parasite survival in the host. The parasite-host cell interaction induces dramatic changes in transcriptome pa...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by RT-PCR Mus musculus Source Type: research
Contributors : Eduardo Ontoria ; Yasmina E Hernandez-Santana ; Ana C Gonzalez-Garc ía ; Manuel C López ; Basilio Valladares ; Emma CarmeloSeries Type : Expression profiling by RT-PCROrganism : Mus musculusLeishmania spp. is a protozoan parasite that affects millions of people around the world. At present, there is no effective vaccine to prevent leishmaniases in humans. A major limitation in vaccine development is the lack of precise understanding of the particular immunological mechanisms that allow parasite survival in the host. The parasite-host cell interaction induces dramatic changes in transcriptome pa...
Source: GEO: Gene Expression Omnibus - Category: Genetics & Stem Cells Tags: Expression profiling by RT-PCR Mus musculus Source Type: research
A genetic study reveals the secrets of how malaria evolved to be deadly killer of humans.
Source: BBC News | Health | UK Edition - Category: Consumer Health News Source Type: news
This article addresses early-life exposure to this unique organic mercury compound (ethylmercury-EtHg) and the risks of its exposure. English language studies pertaining to Thimerosal/EtHg toxicity and exposure during early life were searched in PubMed; and, those publications judged to be relevant to the topic of this review were selected. The risk from the neurotoxic effects of pre- and post-natal Hg exposures depend, in part, on aggravating or attenuating environmental and/or genetic-associated factors. Health authorities in charge of controlling infectious disease dismiss the toxicology of mercury (immunological and su...
Source: Journal of Trace Elements in Medicine and Biology - Category: Biochemistry Source Type: research
Thread Starter Jaundice and splenomegaly? Follow 5 hours ago 5h ago Rather than thinking that they directly cause splenomegaly (they do not), think about the underlying associations. Example: hereditary spherocytosis. Also true for sickle cell disease, thalassaemia, acute malaria, others.... Haemolysis ...
Source: The Student Room - Category: Universities & Medical Training Authors: Tags: Medicine Source Type: forums
Among couples being treated for infertility, depression in the male partner was linked to lower pregnancy chances, according to astudy inFertility and Sterility. In contrast, depression in the female partner was not found to influence the rate of pregnancy or live birth.Depression rates are known to be high among couples seeking fertility treatments, with previous research finding 41% of women and nearly 50% of men in such couples show signs of depression, wrote Emily A. Evans-Hoeker, M.D., of Virginia Tech Carilion, and colleagues.To investigate the role of depression on pregnancy outcomes in couples seeking non-IVF treat...
Source: Psychiatr News - Category: Psychiatry Tags: antidepressants depression Emily A. Evans-Hoeker Esther Eisenberg infertility pregnancy SSRIs Source Type: research
Ramlatu Musaa never met the Emir of Kano State in northern Nigeria. Of course, Ramlatu Musaa hasn’t met a lot of people. She’s only about a week old, born in Kano on April 29, 2018, and yet in some ways, the Emir may have helped saved her life. Two years ago, the polio vaccine was available in Nigeria, but it was still frequently rejected by families. Stray rumors continued to circulate that it was unsafe, able to sicken children and render them infertile. So before one of that year’s national vaccination campaigns began, the Emir—a hereditary leader descended from a ruling family—appeared at ...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized healthytime public health Source Type: news
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