How Imams, Royalty and Family Celebrations are Wiping Out Polio in Nigeria

Ramlatu Musaa never met the Emir of Kano State in northern Nigeria. Of course, Ramlatu Musaa hasn’t met a lot of people. She’s only about a week old, born in Kano on April 29, 2018, and yet in some ways, the Emir may have helped saved her life. Two years ago, the polio vaccine was available in Nigeria, but it was still frequently rejected by families. Stray rumors continued to circulate that it was unsafe, able to sicken children and render them infertile. So before one of that year’s national vaccination campaigns began, the Emir—a hereditary leader descended from a ruling family—appeared at a public ceremony and called for a vial of polio vaccine to be brought to the stage. With the audience watching, he broke its seal and drank down its entire contents. And with that, vaccine resistance in Nigeria retreated one more step. Ramlatu just got her own, much smaller, two-drop dose of the vaccine, the first of eight polio vaccinations she will receive by the time she is nine years old. As it happens, the seven-days-old mark, which immunological science says is the time that the first vaccine dose should be administered, is also when Nigerian tradition says a baby’s naming ceremony should be held. So for Ramlatu, as for many Nigerian newborns, the two occasions were combined. Her celebration and vaccination took place in a small courtyard in a crowded Kano neighborhood, and the event was packed with mothers and children, along with a few repre...
Source: TIME: Health - Category: Consumer Health News Authors: Tags: Uncategorized healthytime public health Source Type: news

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AbstractThe role of viral load in the outcome of patients requiring hospital admission due to influenza is not well established. We aim to assess if there is an association between the viral load and the outcome in hospitalized patients with a confirmed influenza virus infection. A retrospective observational study including all adult patients who were hospitalized in our center with a confirmed influenza virus infection from January to May 2016. Viral load was measured by real-time reverse-transcriptase –polymerase chain reaction (rRT-PCR) cycle threshold (Ct) value on upper respiratory tract samples. Its value was ...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
AbstractDiagnosing a patient with Zika infection is not always straightforward. Here, we aim to describe our data collected from December 2015 to December 2017 and discuss the implemented algorithm and diagnostic challenges we encountered. At the National Reference Center for Arboviruses at the Institute of Tropical Medicine, Antwerp, Belgium (ITM), a commercial Zika virus (ZIKV) enzyme-linked immunosorbent assay (ELISA) detecting immunoglobulin (Ig) M and IgG, a commercial ZIKV immunofluorescence assay (IFA) detecting IgM, and an in-house Zika virus neutralization test (VNT) were implemented. For molecular detection of ZI...
Source: European Journal of Clinical Microbiology and Infectious Diseases - Category: Microbiology Source Type: research
Comparing the role of anti-Müllerian hormone as a marker of FSH action in male and female fertility. Expert Rev Endocrinol Metab. 2019 Mar 04;:1-12 Authors: Urrutia M, Grinspon RP, Rey RA Abstract INTRODUCTION: Originally limited to the assessment of disorders of sex development, anti-Müllerian hormone (AMH) measurement has more recently been extended to several conditions affecting the reproductive axis in males and females. Follicle-stimulating hormone (FSH) regulation of gonadal function has been extensively studied, but its role on AMH production has been explored only recently. Areas cov...
Source: Expert Review of Endocrinology and Metabolism - Category: Endocrinology Tags: Expert Rev Endocrinol Metab Source Type: research
In this study, we used silkworm pupae to develop a safer vaccine for Alzheimer’s disease (AD) patients. Aβ15 peptide was fused with the cholera toxin B subunit (CTB) and expressed in silkworm pupae. Then, we tested an oral vaccine with the peptide expressed by silkworm pupae in a transgenic mouse model of AD. The results show that anti-Aβ antibodies were induced, Aβ deposition in the brain decreased, the content of malondialdehyde was lower than in the other group, and memory and cognition of the mice improved. These results suggest that the high-nutrient CTB-Aβ15 silkworm pupa vaccine has ...
Source: Journal of Biotechnology - Category: Biotechnology Source Type: research
Publication date: Available online 18 March 2019Source: BiologicalsAuthor(s): Shuyun Qin, Dmitriy Volokhov, Elvira Rodionova, Christoph Wirblich, Matthias J. Schnell, Vladimir Chizhikov, Alena DabrazhynetskayaAbstractThe Rapid Fluorescent Focus Inhibition Test (RFFIT) is a standard assay used to detect and assess the titers of rabies virus neutralizing antibodies (RVNA) in blood sera. To simplify the multistep RFFIT procedure by eliminating the immunostaining step, we generated a new recombinant RV expressing a green fluorescent protein (rRV-GFP) and assess its suitability for quantifying RVNA. We rescued the rRV-GFP virus...
Source: Biologicals - Category: Biology Source Type: research
Publication date: Available online 18 March 2019Source: Plant Physiology and BiochemistryAuthor(s): Beatriz Nastaro Boschiero, Eduardo Mariano, Ricardo Antunes Azevedo, Paulo Cesar Ocheuze TrivelinAbstractAlthough ammonium (NH4+) has been claimed as the preferential N source for sugarcane (Saccharum spp.), the intense uptake of this mineral form by plants can impair metabolic processes and crop yield. We aimed to assess the growth, nutrition, and metabolic responses of sugarcane grown under different amounts of nitrate (NO3−) and NH4+. Sugarcane setts were grown in nutrient solution at a total concentration of 15 m...
Source: Plant Physiology and Biochemistry - Category: Biochemistry Source Type: research
Conclusion: LPR may be a risk factor for JORRP, contributing to its development by activating or reactivating a latent HPV infection. Results are in accordance with those from our previous study in adults. PMID: 30881982 [PubMed - in process]
Source: Biomed Res - Category: Research Authors: Tags: Biomed Res Int Source Type: research
Conclusion. The risk factors of postoperative delirium after ASD surgery were PNI less than 49.7 and age more than 68.5 years. Patients who undergo ASD surgery beyond these preoperative cut-off values should be cautioned about delirium and be required to provide adequate informed consent. Level of Evidence: 3
Source: Spine - Category: Orthopaedics Tags: DIAGNOSTICS Source Type: research
Condition:   Vaccination; Infection Intervention:   Biological: Infanrix hexa or Vaxelis Sponsors:   University of Oxford;   MCM Vaccines B.V. Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Ramlatu Musaa never met the Emir of Kano State in northern Nigeria. Of course, Ramlatu Musaa hasn’t met a lot of people. She’s only about a week old, born in Kano on April 29, 2018, and yet in some ways, the Emir may have helped saved her life. Two years ago, the polio vaccine was available in Nigeria, but it was still frequently rejected by families. Stray rumors continued to circulate that it was unsafe, able to sicken children and render them infertile. So before one of that year’s national vaccination campaigns began, the Emir—a hereditary leader descended from a ruling family—appeared at ...
Source: TIME: Science - Category: Science Authors: Tags: Uncategorized healthytime public health Source Type: news
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