Health Tip: Help Prevent E coli Infection

-- Escherichia coli(E. coli) is a bacterium that's found in the environment, foods and intestines of people and animals. Many strains are harmless, but some can make you very sick, causing diarrhea, urinary tract infection, respiratory illness and...
Source: - Daily MedNews - Category: General Medicine Source Type: news

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Uropathogenic Escherichia coli (UPEC) is the causative bacterium in most urinary tract infections (UTIs). UPEC cells adhere to and invade bladder epithelial cells (BECs) and cause uropathogenicity. Invading UPEC cells may encounter one of several fates, including degradation in the lysosome, expulsion to the extracellular milieu for clearance, or survival as an intracellular bacterial community and quiescent intracellular reservoir that can cause later infections. Here we considered the possibility that UPEC cells secrete factors that activate specific host cell signaling networks to facilitate the UPEC invasion of BECs. U...
Source: Journal of Biological Chemistry - Category: Chemistry Authors: Tags: Microbiology Source Type: research
Abstract 50% of Caucasians carry a Thr300Ala variant (T300A) in the protein encoded by the macroautophagy/autophagy gene ATG16L1. Here, we show that the T300A variant confers protection against urinary tract infections (UTIs), the most common infectious disease in women. Using knockin mice carrying the human T300A variant, we show that the variant limits the UTI-causing bacteria, uropathogenic Escherichia coli (UPEC), from establishing persistent intracellular reservoirs, which can seed UTI recurrence. This phenotype is recapitulated in mice lacking Atg16l1 or Atg7 exclusively in the urothelium. We further show th...
Source: Autophagy - Category: Cytology Authors: Tags: Autophagy Source Type: research
CONCLUSIONS: Hemolytic-uremic syndrome rarely occurs after an acute E. coli urinary tract infection. It affects both children and adults and is mostly caused by germs that are shigatoxin-positive. PMID: 30328581 [PubMed - as supplied by publisher]
Source: Journal of Nephrology - Category: Urology & Nephrology Authors: Tags: J Nephrol Source Type: research
This study sought to provide direct evidence of the benefits of drinking extra fluids. What did the study tell us? The study participants were 140 premenopausal women who experienced three or more episodes of cystitis in one year and reported that they drank less than 1.5 liters of fluids daily, which is about 6 1/3 cups. The average amount participants drank daily was a bit over a liter (1.1 liters, or about 4 1/2 cups). The women were randomized to one of two groups. Every day, one group drank their usual amount of fluids plus an additional 1.5 liters of water. The control group drank just their usual amount of fluids. T...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Kidney and urinary tract Prevention Sex Women's Health Source Type: blogs
ConclusionsThe emergency of coexistence of carbapenemase genes and mcr-1 in Enterobacteriaceae highlights the serious threat to antimicrobial therapy.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
ConclusionIn conclusion, the genome sequence of this new UPEC isolate from Pakistan provides novel insight into the genetic attributes of an epidemic clone associated with high level of resistance and virulence.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
We report the case of a 81-year-old female presenting with gastroenteritic symptoms and laboratory findings of a hemolytic anemia, thrombocytopenia and acute renal failure with fatal outcome. A hemolytic-uremic syndrome caused by an infection with EHEC was diagnosed. As a further complication, a urinary tract infection with K. pneumoniae was diagnosed and treated. PMID: 30278845 [PubMed - in process]
Source: Praxis - Category: General Medicine Authors: Tags: Praxis (Bern 1994) Source Type: research
ConclusionRoutine screening of antenatal women during all trimesters must be considered for preventing the adverse maternal and fetal outcomes particularly with known risk factors like low educational level, multiparity and previous history of UTI.
Source: Clinical Epidemiology and Global Health - Category: Epidemiology Source Type: research
CONCLUSION: The cystometric capacity and compliance decreased significantly though patients were doing regular CIC and managed on antimuscarinics for detrusor overactivity (DO). UTI is more common in individuals with SCI with DO and E. coli is the most common cause of UTI. PMID: 30277852 [PubMed - as supplied by publisher]
Source: Journal of Spinal Cord Medicine - Category: Orthopaedics Tags: J Spinal Cord Med Source Type: research
In this study, comparative sRNA analysis across three different members of Enterobacteriaceae (Escherichia coli, Salmonella typhi and Salmonella typhimurium) was carried out to identify the sRNA homologs in P. mirabilis. A total of 232 sRNA genes that were reported in E. coli, S. typhi and S. typhimurium were subjected to comparative analysis against P. mirabilis HI4320 genome. We report the detection of 14 sRNA candidates, conserved in the orthologous regions of P. mirabilis, that are not included in Rfam database. Northern-blot analysis was carried out for selected three sRNA candidates from the current investigation and...
Source: Molecular Biology Reports - Category: Molecular Biology Authors: Tags: Mol Biol Rep Source Type: research
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