Polymyalgia rheumatica and diverticular disease: just two distinct age-related disorders or more? Results from a case-control study

AbstractIn a previous report of two married cohabiting couples affected by polymyalgia rheumatica (PMR), we noticed that the wife of one couple and both members of the other couple suffered from symptomatic diverticular disease (DD), whose diagnosis was made before the onset of PMR. We investigated whether DD might be a risk factor for the development of PMR. We conducted a case-control study informed on a database containing the prospectively collected medical records of consecutive PMR patients. Among comorbidities, attention was focused on symptomatic DD, provided that the diagnosis had been made by colonoscopy and/or computed tomography scan. As controls, we identified one control per case at random among those matched by age and sex attending the ophthalmic and orthopedic outpatient clinics, as long as a PMR diagnosis had been excluded. A logistic regression model was used, following a multiplicative model, and results were presented as odds ratio (OR) and 95% confidence intervals (95% CI). The most frequent comorbidities in the two groups of patients (121 cases and 121 controls) were chronic coronary artery disease, atrial fibrillation, diabetes mellitus, hypertension, DD, hypercholesterolemia, osteoporosis, chronic obstructive pulmonary disease, gastroesophageal reflux disease, and cholelithiasis. The association between PMR and DD (OR  = 4.06; 95% CI: 1.76–9.35) was by far stronger than that found comparing PMR with the other comorbidities. The chr...
Source: Clinical Rheumatology - Category: Rheumatology Source Type: research

Related Links:

Publication date: Available online 24 January 2020Source: Journal of Genetics and GenomicsAuthor(s): Qianru Huang, Xu Liu, Yujia Zhang, Jingyao Huang, Dan Li, Bin LiAbstractRegulatory T (Treg) cells, a subtype of CD4+ T cells with distinct immunosuppressive, are vital for maintaining immune homeostasis in healthy people. FOXP3 (Forkhead box protein P3), a member of the forkhead–winged-helix family, is the pivotal transcriptional factor of Treg. The expression, post-translational modifications and protein complex of FOXP3 present a great impact on the functional stability and immune plasticity of Treg in vivo. In part...
Source: Journal of Genetics and Genomics - Category: Genetics & Stem Cells Source Type: research
PMID: 31977420 [PubMed - in process]
Source: The American Journal of Nursing - Category: Nursing Authors: Tags: Am J Nurs Source Type: research
Publication date: Available online 24 January 2020Source: The American Journal of SurgeryAuthor(s): Jason M. Bowie, Richard Y. Calvo, Vishal Bansal, Lyndsey E. Wessels, William J. Butler, C. Beth Sise, Jennifer G. Shaw, Michael J. SiseAbstractBackgroundComplicated gallstone disease (CGD) is a common condition requiring intervention during pregnancy to avert adverse birth outcomes (ABO).MethodsCohort study using the California OSHPD 2007–2014 database. Records of pregnant patients were analyzed for gallbladder calculus within four months of delivery. Biliary system interventions were evaluated as the primary exposure....
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionWe present the first risk score model to predict IGBC. The model estimates the expected risk for the individual patient and may help to optimize treatment strategies.
Source: The American Journal of Surgery - Category: Surgery Source Type: research
ConclusionsThis is the largest series to date reporting>30-day follow-up for patients undergoing venous ablation procedures while receiving anticoagulation and the longest follow-up reported of any series. Durability, safety, and efficacy of vein ablation in patients receiving anticoagulation are comparable to those in control patients. Anticoagulation should not be considered a contraindication to endothermal ablation of the GSV or SSV for symptomatic venous reflux.
Source: Journal of Vascular Surgery: Venous and Lymphatic Disorders - Category: Surgery Source Type: research
CONCLUSIONS The findings suggested that Doxy can profoundly mitigate atrial fibrosis, conduction inhomogeneity as well as high AF inducibility secondary to fibrosis in a CIH rat model through suppressing the TGF-ß1 signaling pathway. PMID: 31974331 [PubMed - in process]
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Publication date: Available online 24 January 2020Source: Pulmonary Pharmacology &TherapeuticsAuthor(s): Monielle Sant’Ana Leal, Helena R. Souza, Lucas Possebon, Marinônio L. Cornélio, Yanira Riffo-Vasquez, Ana Paula Girol, Sonia M. OlianiAbstractChronic obstructive pulmonary disease (COPD) is related to smoking and anti-inflammatory therapy is indicated. Among the mediators with anti-inflammatory properties, we highlight piperlongumine (PL), an alkaloid/amide of Piper longum. Here we evaluated the PL administration on an experimental model of respiratory inflammation resulting from exposure to cigar...
Source: Pulmonary Pharmacology and Therapeutics - Category: Respiratory Medicine Source Type: research
Publication date: Available online 24 January 2020Source: Journal of Vascular and Interventional RadiologyAuthor(s): Yumei Yang, Yanfang Zhang, Yumin Wu, Jibing Chen, Bing Liang, Quanhong Chen, Qiuyu Wang, Jialing Lyu, Yong Li, Feng Mu, Duanming DuAbstractPurposeTo evaluate the efficacy and safety of percutaneous argon-helium cryoablation (CA) for hepatocellular carcinoma (HCC) abutting the diaphragm (
Source: Journal of Vascular and Interventional Radiology - Category: Radiology Source Type: research
Abstract The current qualitative study explored perceptions and experiences of chronic obstructive pulmonary disease (COPD) among Korean male older adults. Six older adults participated in a narrative group interview. Responses were analyzed to describe perceptions and experiences of COPD. Social stigma, blaming others and the environment, stress to bear alone, and adaptation and management emerged as relevant themes for adaptation to COPD. In relation to obstacles to healthy behaviors after adapting to COPD, emergent themes were adapting to symptoms, external environmental factors, alternative treatments, and ins...
Source: Journal of Gerontological Nursing - Category: Nursing Authors: Tags: J Gerontol Nurs Source Type: research
This article reviews the state of the art and major unanswered questions related to ocular vascular anatomy and physiology, ocular imaging techniques, clinical findings in glaucoma and other eye diseases, and mechanistic modeling predictions, while laying a path for integrating clinical observations with mathematical models and artificial intelligence. Viable alternatives for integrated data analysis are proposed that aim to overcome the limitations of standard statistical approaches and enable individually tailored precision medicine in ophthalmology.
Source: Progress in Retinal and Eye Research - Category: Opthalmology Source Type: research
More News: Acid Reflux | Atrial Fibrillation | Chronic Obstructive Pulmonary | Colonoscopy | CT Scan | Databases & Libraries | Diabetes | Diabetes Mellitus | Diverticular Disease | Endocrinology | Gallstones | Gastroenterology | Gastroesophageal Reflux Disease | GERD | Hypertension | Opthalmology | Orthopaedics | Osteoporosis | PET Scan | Polymyalgia Rheumatica | Rheumatology | Study