Viruses, Vol. 10, Pages 244: An Ointment Consisting of the Phage Lysin LysGH15 and Apigenin for Decolonization of Methicillin-Resistant Staphylococcus aureus from Skin Wounds
Viruses, Vol. 10, Pages 244: An Ointment Consisting of the Phage Lysin LysGH15 and Apigenin for Decolonization of Methicillin-Resistant Staphylococcus aureus from Skin Wounds
Viruses doi: 10.3390/v10050244
Authors:
Mengjun Cheng
Lei Zhang
Hao Zhang
Xinwei Li
Yanmei Wang
Feifei Xia
Bin Wang
Ruopeng Cai
Zhimin Guo
Yufeng Zhang
Yalu Ji
Changjiang Sun
Xin Feng
Liancheng Lei
Yongjun Yang
Wenyu Han
Jingmin Gu
Staphylococcus aureus (S. aureus) is a common and dangerous pathogen that causes various infectious diseases. Skin damage, such as burn wounds, are at high risk of Staphylococcus aureus colonization and infection, which increases morbidity and mortality. The phage lysin LysGH15 exhibits highly efficient lytic activity against methicillin-resistant S. aureus (MRSA) and methicillin-susceptible S. aureus (MSSA) strains. Apigenin (api) significantly decreases haemolysis of rabbit erythrocytes caused by S. aureus and shows anti-inflammatory function. LysGH15 and api were added to Aquaphor to form an LysGH15-api-Aquaphor (LAA) ointment. The LAA ointment simultaneously exhibited bactericidal activity against S. aureus and inhibited haemolysis. In an LAA-treated mouse model of an MRSA-infected skin wound, the mean bacterial colony count decreased to approximately 102 CFU/mg at 18 h after treatment (and the bacteria became undetectable at 96 h), whereas the mean count in untreated mice was approximately 105 CFU/mg of tissue. The LAA ointment also...
Source: Viruses - Category: Virology Authors: Mengjun Cheng Lei Zhang Hao Zhang Xinwei Li Yanmei Wang Feifei Xia Bin Wang Ruopeng Cai Zhimin Guo Yufeng Zhang Yalu Ji Changjiang Sun Xin Feng Liancheng Lei Yongjun Yang Wenyu Han Jingmin Gu Tags: Article Source Type: research
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