Smoking and Death; Vessels for CABG: It's PodMed Double T! (with audio)

(MedPage Today) -- This week's topics include the best blood vessel for cardiac bypass grafts, rates of autism, five healthy lifestyle factors and their impact on mortality, and managing COPD
Source: MedPage Today Pulmonary - Category: Respiratory Medicine Source Type: news

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Objective: Considering the potential role of lymphocytes in the pathophysiology of autism spectrum disorder (ASD), we aimed to evaluate possible alterations of T cell pools in the lymphoid organs of an animal model of autism induced by valproic acid (VPA). Pregnant Swiss mice received a single intraperitoneal injection of 600 mg/kg of VPA (VPA group) or saline (control group) on day 11 of gestation. Male offspring were euthanized on postnatal day 60 for removal of thy ­muses, spleens, and a pool of inguinal, axillary and brachial lymph nodes. Cellularity was evaluated, and flow cytometry analysis was performed on cell ...
Source: Neuroimmunomodulation - Category: Allergy & Immunology Source Type: research
The five Muscarinic Acetylcholine (ACh) receptors are G-protein coupled receptors (M1R-M5R). M1R, M3R and M5R selectively couple to Gq/G11; M2R and M4R selectively couple to Gi/Go. M3 muscarinic ACh receptors are present in the central nervous system and the periphery.M3R knockout mice are viable and fertile, and have no major morphological abnormalities. They have a lean phenotype. This results from a combination of reduced caloric intake and increased energy expenditure. They eat less food than wild-type mice, possibly because a central cholinergic pathway that stimulates food intake is disrupted. They also expend more e...
Source: NIDDK Research Resources - Category: Endocrinology Source Type: research
Authors: Kim SH, Kim HJ, Hwang HY Abstract A 73-year-old woman who underwent combined bioprosthetic mitral valve replacement, tricuspid ring annuloplasty, and coronary artery bypass grafting 12 years previously visited our clinic due to aggravated dyspnea caused by structural valve deterioration of the mitral prosthesis. Because aortic or femoral artery cannulation and cross-clamping would have a high risk of stroke owing to severe calcification of the ascending aorta and ilio-femoral vessels, and because there was a risk of redo sternotomy due to the patent bypass grafts, a comprehensive approach including axillar...
Source: Korean Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Tags: Korean J Thorac Cardiovasc Surg Source Type: research
Condition:   COPD Intervention:   Other: Dance Sponsors:   West Park Healthcare Centre;   Canadian Lung Association Completed
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Conditions:   Alpha 1-Antitrypsin Deficiency;   Emphysema;   COPD Interventions:   Drug: Placebo Oral Tablet;   Drug: Alvelestat oral tablet - dose 1;   Drug: Alvelestat oral tablet - dose 2 Sponsors:   Mereo BioPharma;   Syneos Health Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Leonardo Emberti Gialloreti, Paolo Curatolo
Source: Frontiers in Neurology - Category: Neurology Source Type: research
Miguel Á García-Cabezas, Helen Barbas, Basilis Zikopoulos
Source: Frontiers in Neuroanatomy - Category: Neurology Source Type: research
The level of DDT exposure to pregnant women correlates with an increased risk of autism in their children, according to a study in theAmerican Journal of Psychiatry. Medical News Today
Source: Society for Endocrinology - Category: Endocrinology Source Type: news
Conclusion: While the integrated, per capita, exposure of PM for a large fraction of the first-world may be less than 1 mg per day, links between several syndromes, including attention deficit hyperactivity disorder (ADHD), autism, loss of cognitive function, anxiety, asthma, chronic obstructive pulmonary disease (COPD), hypertension, stroke, and PM exposure have been suggested. This article reviews and summarizes such links reported in the literature.
Source: Journal of Occupational and Environmental Medicine - Category: Occupational Health Tags: Original Articles Source Type: research
Conclusion: Going beyond the powerful scientific and economic arguments for urgent action to reduce the burning of fossil fuels is the strong moral imperative to protect our most vulnerable populations. Citation: Perera FP. 2017. Multiple threats to child health from fossil fuel combustion: impacts of air pollution and climate change. Environ Health Perspect 125:141–148; http://dx.doi.org/10.1289/EHP299 Address correspondence to F.P. Perera, Department of Environmental Health Sciences, Columbia Center for Children’s Environmental Health, Columbia University Mailman School of Public Health, 722 West 168th St. ...
Source: EHP Research - Category: Environmental Health Authors: Tags: Commentaries Children's Health February 2017 Source Type: research
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