Targeted Therapy and Immunotherapy in the Treatment of Non –Small Cell Lung Cancer

The treatment strategy in advanced non –small cell lung cancer (NSCLC) has evolved from empirical chemotherapy to a personalized approach based on histology and molecular markers of primary tumors. Targeted therapies are directed at the products of oncogenic driver mutations. Immunotherapy facilitates the recognition of cancer as forei gn by the host immune system, stimulates the immune system, and alleviates the inhibition that allows the growth and spread of cancer cells. The authors describes the role of targeted therapy and immunotherapy in the treatment of NSCLC, patterns of disease present on imaging studies, and immune-rela ted adverse events encountered with immunotherapy.
Source: Radiologic Clinics of North America - Category: Radiology Authors: Source Type: research