The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss.

The Role of c-Jun N-Terminal Kinase (JNK) in Retinal Degeneration and Vision Loss. Adv Exp Med Biol. 2018;1074:351-357 Authors: Kim BJ, Zack DJ Abstract c-Jun N-terminal kinase (JNK), a member of stress-induced mitogen-activated protein (MAP) kinase family, has been shown to modulate a variety of biological processes associated with neurodegenerative pathology of the retina. In particular, various retinal cell culture and animal models related to glaucoma, age-related macular degeneration (AMD), and retinitis pigmentosa indicate that JNK signaling may contribute to disease pathogenesis. This mini-review discusses the impact of JNK signaling in retinal disease, with a focus on retinal ganglion cells (RGCs), photoreceptor cells, retinal pigment epithelial (RPE) cells, and animal studies, with particular attention to modulation of JNK signaling as a potential therapeutic target for the treatment of retinal disease. PMID: 29721963 [PubMed - in process]
Source: Advances in Experimental Medicine and Biology - Category: Research Tags: Adv Exp Med Biol Source Type: research