RUNX1 promotes cell growth in human T-cell acute lymphoblastic leukemia by transcriptional regulation of key target genes

The RUNX1 gene, a member of the RUNT-related transcription factor family, is dysregulated in many types of hematologic malignancy [1]. It was first identified as a partner with ETO in t(8;21) acute myelogenous leukemia (AML), and later with TEL/ETV6 in t(12;21) B-lineage acute lymphoblastic leukemia and with EVI1/MECOM in t(3;21) therapy-related AML/myelodysplastic syndrome (MDS). Point mutations and small indels in RUNX1 have been described in MDS/AML and familial platelet disorder with associated myeloid malignancy [2] and more recently in T-cell acute lymphoblastic leukemia (T-ALL) [3 –6].

Source: Experimental Hematology - May 4, 2018 Category: Hematology Authors: Catherine E. Jenkins, Samuel Gusscott, Rachel J. Wong, Olena O. Shevchuk, Gurneet Rana, Vincenzo Giambra, Kateryna Tyshchenko, Rashedul Islam, Martin Hirst, Andrew P. Weng Tags: Malignant Hematopoiesis Source Type: research