Clinical Trial Strategies to Compare Protons With Photons
The favorable beam properties of protons can be translated into clinical benefits by target dose escalation to improve local control without enhancing unacceptable radiation toxicity or to spare normal tissues to prevent radiation-induced side effects without jeopardizing local tumor control. For the clinical validation of the added value of protons to improve local control, randomized controlled trials are required. For the clinical validation of the added value of protons to prevent side effects, both model-based validation or randomized controlled trials can be used.
Source: Seminars in Radiation Oncology - Category: Cancer & Oncology Authors: Johannes A. Langendijk, Liesbeth J. Boersma, Coen R.N. Rasch, Marco van Vulpen, Johannes B. Reitsma, Arjen van der Schaaf, Ewoud Schuit Source Type: research