Comparing Intensity-Modulated Proton Therapy With Intensity-Modulated Photon Therapy for Oropharyngeal Cancer: The Journey From Clinical Trial Concept to Activation

Intensity-modulated proton therapy minimizes the incidental irradiation of normal tissues in patients with head and neck cancer relative to intensity-modulated photon (x-ray) therapy and has been associated with lesser treatment-related toxicity and improved quality of life. A phase II/III randomized trial sponsored by the US National Cancer Institute is currently underway to compare deintensification treatment strategies with intensity-modulated proton therapy vs intensity-modulated photon (x-ray) therapy for patients with advanced-stage oropharyngeal tumors.

Source: Seminars in Radiation Oncology - April 1, 2018 Category: Cancer & Oncology Authors: Steven J. Frank, Pierre Blanchard, J. Jack Lee, Erich M. Sturgis, Merrill S. Kies, Mitchell Machtay, Bhadrasain Vikram, Adam S. Garden, David I. Rosenthal, G. Brandon Gunn, C. David Fuller, Katherine Hutcheson, Stephen Lai, Paul M. Busse, Nancy Y. Lee, Al Source Type: research