Polygenic Risk Score and the (neuro)developmental ontogenesis of the schizophrenia spectrum vulnerability phenotypes

Mistry et al. (Mistry et al., 2017)'s recent overview on schizophrenia Polygenic Risk Score (s-PRS) and related phenotypic manifestations clearly indicates the potential of such an approach for understanding the liability for schizophrenia. Briefly, available empirical literature seems to converge on four major key-points: 1) pleiotropy between schizophrenia and other disorders (e.g. schizo-affective, bipolar, depressive and anxiety disorders); 2) less common-variant genetic overlap between schizophrenia and cognition than with other psychopathology; 3) small proportion of variance explained by currently available s-PRS for all phenotypes (presumably limited by the fact that PRS does not capture Copy Number Variants or rare Single Nucleotide Polymorphism contributions to variance); 4) early ontogenetic expression of genetic risk for schizophrenia in the general population through a broad range of soft (i.e.
Source: Schizophrenia Research - Category: Psychiatry Authors: Tags: Letter to the editor Source Type: research