Nevus or Melanoma of the Iris? A Progressive Course Over at Least 43 Years.

[Nevus or Melanoma of the Iris? A Progressive Course Over at Least 43 Years]. Klin Monbl Augenheilkd. 2018 May 03;: Authors: Rohrbach JM, Süsskind D, Bartz-Schmidt KU PMID: 29723886 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research

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Paolo Perri Uveal melanoma (UM), which is the most common cancer of the eye, was investigated in recent years by many teams in the field of biomedical sciences and eye clinicians. New knowledge was acquired on molecular pathways found to be dysregulated during the multistep process of oncogenesis, whereas novel therapeutic approaches gave significant results in the clinical applications. Uveal melanoma-affected patients greatly benefited from recent advances of the research in this eye cancer. Tumour biology, genetics, epigenetics and immunology contributed significantly in elucidating the role of different genes and r...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Review Source Type: research
We would like to comment on Harbour and associates ’ American Ophthalmological Society thesis “Are risk factors for growth of choroidal nevi associated with malignant transformation? Assessment with a validated genomic biomarker.”1 The authors found that of the many clinical features associated with “malignant transformation” of a melanocy tic tumor, only 2, tumor thickness greater than 2.25 mm and patient age (over 60), are significant. There are likely a few exceptions to this, such as diffuse melanoma.
Source: American Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Correspondence Source Type: research
Authors: Malosse L, Angioi K, Baumann C, Rousseau H, Conart JB Abstract PURPOSE: To determine the diagnostic and functional yield of vitrectomy in patients with uveitis of unknown origin. METHODS: A single-centered retrospective study was performed on patients who underwent a diagnostic vitrectomy for uveitis in the Department of Ophthalmology of the Nancy University Hospital from January 2011 to December 2016. Vitreous samples were analyzed in the cytology laboratory by cytological and immunohistochemical techniques, and in the microbiological laboratory by culture and bacterial, fungal and viral PCR, dep...
Source: Journal Francais d Ophtalmologie - Category: Opthalmology Tags: J Fr Ophtalmol Source Type: research
Conclusion: The effect of106Ru plaque treatment on fundus UW imaging is detected as homogenous and well-demarcated hyperautofluorescence before visible RPE atrophy.Ocul Oncol Pathol
Source: Ocular Oncology and Pathology - Category: Opthalmology Source Type: research
Abstract OBJECTIVE: To determine the frequency and amount of visual improvement in amblyopic eyes of adults following visual loss in the dominant eye resulting from treatment of uveal melanoma. METHODS AND ANALYSIS: Retrospective case series of adult patients with amblyopia and dominant eye visual loss resulting from treatment of uveal melanoma. Review of best-corrected visual acuity (BCVA) in each eye (amblyopia eye vs melanoma eye) at date first seen and over time following treatment of uveal melanoma. BCVA in each eye was graded as improved (>2 logarithm of minimal angle of resolution (logMAR) lines) or unimproved (
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
CONCLUSIONS: This analysis demonstrates novel variations in CM incidence rates between different Canadian provinces. These results taken together with the data reported from the USA confirm the North-to-South geographic gradient of increasing CM incidence. This research highlights that the epidemiology of CM in North America is comparable to that of cutaneous malignant melanoma in contrast to the trends for uveal melanoma distribution. PMID: 31079055 [PubMed - as supplied by publisher]
Source: The British Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Br J Ophthalmol Source Type: research
Publication date: Available online 8 May 2019Source: The Veterinary JournalAuthor(s): J.G. Rushton, M. Korb, S. Kummer, U. Reichart, A. Fuchs-Baumgartinger, A. Tichy, B. NellAbstractFeline iris melanoma, the most common feline intraocular tumour, has a reported metastatic rate of 19–63%. However, there is a lack of knowledge about its molecular biology. Previous studies have reported that feline iris melanomas do not harbour mutations comparable to common mutations found in their human counterpart. Nevertheless, there are differences in the gene expression patterns. The aim of this study was to investigate the protei...
Source: The Veterinary Journal - Category: Veterinary Research Source Type: research
AbstractInflammation in uveal melanoma (UM) is linked to a bad prognosis. It is rare type of cancer, of which the metastases are usually fatal within a year. Infiltration with an inflammatory infiltrate increases with disease progression but does not seem to inhibit metastasis. The Canonical NF κB (C-NFκB) pathway is known to play a crucial role in tumor inflammation. We therefore, studied the expression of canonical NFκB proteins and their prognostic relevance in UM. Our study evaluated the expression of C-NFκB proteins (p65, p50, and c-Rel) by using immunohistochemistry on sections f rom 75 formal...
Source: Clinical and Experimental Metastasis - Category: Cancer & Oncology Source Type: research
New England Journal of Medicine,Volume 380, Issue 19, Page 1853-1853, May 2019.
Source: New England Journal of Medicine - Category: Internal Medicine Authors: Source Type: research
Conditions:   Choroidal Melanoma;   Indeterminate Lesions of Eye Intervention:   Sponsor:   Aura Biosciences Recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
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