Nevus or Melanoma of the Iris? A Progressive Course Over at Least 43 Years.

[Nevus or Melanoma of the Iris? A Progressive Course Over at Least 43 Years]. Klin Monbl Augenheilkd. 2018 May 03;: Authors: Rohrbach JM, Süsskind D, Bartz-Schmidt KU PMID: 29723886 [PubMed - as supplied by publisher]
Source: Klinische Monatsblatter fur Augenheilkunde - Category: Opthalmology Tags: Klin Monbl Augenheilkd Source Type: research

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To describe the superiority of ocular ultrasound in the diagnostic management of extrascleral extension in choroidal melanoma.
Source: BMC Ophthalmology - Category: Opthalmology Authors: Tags: Case report Source Type: research
Conditions:   Cancer;   Melanoma (Skin);   Melanoma, Uveal;   Melanoma, Ocular;   Bladder Cancer;   Mismatch Repair Deficiency;   Microsatellite Instability;   Non-melanoma Skin Cancer Interventions:   Biological: RP1;   Biological: nivolumab Sponsor:   Replimune Inc. Recruiting
Source: - Category: Research Source Type: clinical trials
CONCLUSION: For the primary treatment of iridal melanoma a surgical, eyeball-sparing approach and also when appropriate, radiotherapy can be recommended. In the future, eligible high-risk patients could profit from a tumor vaccination. To date, there is no effective systemic treatment for metastatic iridal melanoma. PMID: 30515574 [PubMed - as supplied by publisher]
Source: Der Ophthalmologe - Category: Opthalmology Authors: Tags: Ophthalmologe Source Type: research
This secondary analysis of medical records assesses the specific risks of plaque-irradiated small choroidal melanoma on visual acuity and metastasis for small choroidal melanoma 3 mm thick or less.
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research
Over the last several decades, ocular oncologists have set a goal to identify and treat smaller uveal melanomas. Another way to rephrase this goal would be to state that we want to identify melanocytic lesions that are likely to spread at some future time and ablate them before they do so. Ocular oncologists are very accurate in diagnosing medium and large uveal melanomas. Differentiation of small melanomas from high-risk choroidal nevi has been more challenging. Approximately 8% of people in the United States have a choroidal nevus. The malignant transformation rate is estimated at about 1 in 9000 per year. This translate...
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research
To the Editor We read with great interest the article by Dalvin et al concerning the association between myotonic dystrophy (DM1) and uveal melanoma. Recent evidence has shown that uveal melanoma is associated with mutations in genes responsible for the eye colors, with a higher disease prevalence in individuals with lighter-colored eyes. We agree with the authors on the importance of an accurate ophthalmic examination in patients with DM1, because they may present with many ophthalmic diseases across the life span. However, we believe it is important to put their findings into context with other large studies.
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research
In Reply We appreciate the important points raised by our colleagues in Italy, Rosa et al and Silvestri et al, regarding the association between uveal melanoma and myotonic dystrophy. Detecting an association between 2 rare diseases can present a challenge. We cited a prior publication from Win et al describing a 28-fold increased risk of uveal melanoma in patients with myotonic dystrophy, based on the detection of 2 cases in 307 patients. We then presented 6 additional cases, exemplifying this association. The letter from Rosa et al and a study by Bianchi et al describe no cases of uveal melanoma in 268 and 255 Italian pa...
Source: JAMA Ophthalmology - Category: Opthalmology Source Type: research
PMID: 30503012 [PubMed - in process]
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
Abstract Uveal melanoma is the most common intraocular primary malignant tumor in adults, and retinoblastoma is the one in children. Current mainstay treatment options include chemotherapy using conventional drugs and enucleation, the total removal of the eyeball. Targeted therapies based on profound understanding of molecular mechanisms of ocular tumors may increase the possibility of preserving the eyeball and the vision. Tyrosine kinases, which modulate signaling pathways regarding various cellular functions including proliferation, differentiation, and attachment, are one of the attractive targets for targeted...
Source: Archives of Pharmacal Research - Category: Drugs & Pharmacology Authors: Tags: Arch Pharm Res Source Type: research
AbstractWe appraise the role of screening for distress as part of health psychology assessment of patients newly diagnosed with cancer. We reviewed records of consecutive patients who accepted a health psychologist ’s assessment over 4 years, examining convergence and divergence of the result of screening (whether patients reached threshold as ‘cases’) with the psychologist’s clinical judgment of need for intervention. Of 261 patients, 88 (33.7%) were ‘cases’. Of these, need for psychological inte rvention was identified in 70 (79.5%). Of the 173 (66.3%) ‘non-cases’, nee...
Source: Journal of Clinical Psychology in Medical Settings - Category: Psychiatry & Psychology Source Type: research
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