Niacin With Statins? No Dice.Niacin With Statins? No Dice.

Wilbert Aronow comments on the trial that slammed the door on niacin for lipid-lowering. Faculty of 1000
Source: Medscape Today Headlines - Category: Consumer Health News Tags: Family Medicine/Primary Care Commentary Source Type: news

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Publication date: 15 February 2019Source: Chemical Engineering Journal, Volume 358Author(s): Tingting Liu, Lei Wang, Chenxu Sun, Xiu Liu, Rui Miao, Yongtao LvAbstractFluvastatin, a commonly used cholesterol-lowering drug, has attracted considerable attention because of its adverse effects on human beings. Photolysis and ZnIn2S4 photocatalysis of fluvastatin under UV–Vis irradiation were compared based on analysis of reactive oxygen species (ROS), degradation pathways, and toxicity evaluation. The removal rates of fluvastatin by photolysis and photocatalysis were 71.07% and 99.79%, respectively. Photolytic degradation...
Source: Chemical Engineering Journal - Category: Chemistry Source Type: research
Authors: Han KH Abstract HMG-CoA reductase inhibitors, i.e. statins, are effective in reducing cardiovascular disease events but also in cardiac-related and overall mortality. Statins are in general well-tolerated, but currently the concerns are raised if statins may increase the risk of new-onset diabetes mellitus (NOD). In this review, the possible effects of statins on organs/tissues being involved in glucose metabolism, i.e. liver, pancreas, adipose tissue, and muscles, had been discussed. The net outcome seems to be inconsistent and often contradictory, which may be largely affected by in vitro experimental se...
Source: Korean Circulation Journal - Category: Cardiology Tags: Korean Circ J Source Type: research
AbstractBackgroundStatins are often discontinued in patients with advanced cancer since the net effect of treatment is considered negative. However, guidelines concerning discontinuation of statin treatment are lacking. The aim of this study was to investigate any differences in time of discontinuation of statin treatment between men and women with advanced cancer disease.MethodsMedical records from 195 deceased palliative cancer patients from a previous study cohort were reviewed. Patients treated with statins 2  years before death were identified as “statin users.” The time of discontinuation of statin t...
Source: Biology of Sex Differences - Category: Biology Source Type: research
AbstractAtherosclerosis is a complex disease process. It is increasingly recognised that both lipoprotein retention and inflammatory cellular components are intricately related in the initiation and development of atherosclerotic plaque. LDL-c (cholesterol) has been long established as a cause for atherosclerosis; additionally, inflammatory cells such as monocytes and subsequently foam cells have also been directly linked to the progression of atherosclerotic disease. Emerging data suggest that structures outside vascular intima and media are also closely related to atherosclerosis. Perivascular adipose tissue (PVAT) may b...
Source: Indian Journal of Thoracic and Cardiovascular Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
CONCLUSIONS: Statin therapy can cause a significant increase in hsTnT levels after moderate exercise. This increase can jeopardise the accuracy of clinical diagnoses based on the newly implemented algorithms. The awareness of these adverse effects of statins, mainly used by patients with high risk of coronary events, can prevent misdiagnosis or unnecessary hospitalisations. PMID: 30328783 [PubMed - as supplied by publisher]
Source: Acta Cardiologica - Category: Cardiology Tags: Acta Cardiol Source Type: research
Australia's competition watchdog said on Friday the High Court dismissed its special leave application to appeal a court's decision on whether Pfizer Inc's local unit used its market power to limit competition for its cholesterol-lowering drug Lipitor.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Australia's competition watchdog said on Friday the High Court dismissed its special leave application to appeal a court's decision on whether Pfizer Inc's local unit used its market power to limit competition for its cholesterol-lowering drug Lipitor.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
Authors: Okopień B, Bułdak Ł, Bołdys A Abstract INTRODUCTION: The need to reduce residual cardiovascular risk led to the development of novel therapeutic strategies to improve patients' outcomes. The residual risk in people with atherogenic dyslipidemia, despite LDL reduction obtained mainly by statins, remains high. Fibrates in those patients lead to significant clinical improvements. Those include reduction in the progression of atherosclerosis, which translates into decrease in cardiovascular events and improvements in microvascular diabetic complications. Furthermore there are other clinical and biochemical...
Source: Expert Review of Clinical Pharmacology - Category: Drugs & Pharmacology Tags: Expert Rev Clin Pharmacol Source Type: research
Though heart is known primarily as a pump, it is the four cardiac valves that ensures the critical , non-stop unidirectional flow that sustain the circulation . It is to be recalled these valves originate in the very early days of cardiac development when the primitive heart tube loops , even as the chambers expand from primitive ventricle. Mesenchymal differentiation controlled by various genes that cleaves the valve from myocardial tissue. While heart by itself is the supreme vascular organ ,  its surprising  few structures inside the heart , like the valves are quiet avascular ( or is it really so ?)...
Source: Dr.S.Venkatesan MD - Category: Cardiology Authors: Tags: cardiac embryology Embryology : Heart valve development Infective endocarditis : Pathology valvular heart disease blood supply to heart valves hematogenous spread of infective endocarditis how bacteria reach mitral valve in infective endocardi Source Type: blogs
No abstract available
Source: Neurology Today - Category: Neurology Tags: NeuroTech Source Type: research
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