Recommendations to report and interpret HLA genetic findings in coeliac disease.

Recommendations to report and interpret HLA genetic findings in coeliac disease. Rev Esp Enferm Dig. 2018 May 03;: Authors: Núñez C, Garrote JA, Arranz E, Bilbao JR, Fernández Bañares F, Jiménez J, Perucho T, Ruiz Casares E, Sánchez-Valverde F, Serrano N Abstract Coeliac disease (CD) is a chronic autoimmune enteropathy triggered by gluten and related prolamines in genetically predisposed individuals. Although CD is a polygenic disease, there is a strong association with genes of the human leukocyte antigen (HLA) region. Most patients present the HLA-DQ2 heterodimer, specifically the DQ2.5 isoform, which is present in around 90-96% of patients of European ancestry. PMID: 29722267 [PubMed - as supplied by publisher]
Source: Revista Espanola de Enfermedades Digestivas - Category: Gastroenterology Tags: Rev Esp Enferm Dig Source Type: research