CETP (Cholesteryl Ester Transfer Protein) Concentration: A Genome-Wide Association Study Followed by Mendelian Randomization on Coronary Artery Disease [Original Articles]

Conclusions:
This is the first genome-wide association study identifying independent variants that largely determine CETP concentration. Although high-density lipoprotein cholesterol is not a causal risk factor for CAD, it has been unequivocally demonstrated that low-density lipoprotein cholesterol lowering is proportionally associated with a lower CAD risk. Therefore, the results of our study are fully consistent with the notion that CETP concentration is causally associated with CAD through low-density lipoprotein cholesterol.

Source: Circulation: Cardiovascular Genetics - May 4, 2018 Category: Cardiology Authors: Blauw, L. L., Li-Gao, R., Noordam, R., de Mutsert, R., Trompet, S., Berbee, J. F. P., Wang, Y., van Klinken, J. B., Christen, T., van Heemst, D., Mook-Kanamori, D. O., Rosendaal, F. R., Jukema, J. W., Rensen, P. C. N., Willems van Dijk, K. Tags: Lipids and Cholesterol, Cardiovascular Disease, Genetic, Association Studies, Genetics Original Articles Source Type: research