Osteoporosis drug could be used to treat aggressive form of breast cancer, researchers say

(Rockefeller University Press) Researchers in China have discovered that an enzyme called UGT8 drives the progression of basal-like breast cancer, an aggressive form of the disease that is largely untreatable. But the study, which will be published May 4 in the Journal of Experimental Medicine, reveals that the widely used osteoporosis drug zoledronic acid inhibits UGT8 and prevents the spread of basal-like breast cancer in mice, suggesting that this drug could also be used to treat the disease in humans.
Source: EurekAlert! - Cancer - Category: Cancer & Oncology Source Type: news

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Background: Systemic breast cancer therapies interfere with bone turnover and predispose patients to cancer-treatment related bone loss. Breast cancer survivors are at an increased risk for osteoporosis and fracture compared with women in general.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: POSTERS A: Lifestyle, Prevention including Secondary Prevention Source Type: research
Background: Aromatase inhibitors (AI ’s) are the gold standard adjuvant treatment for post-menopausal women with oestrogen-receptor positive breast cancer (BC) but accelerate bone loss and increase fracture risk.
Source: European Journal of Cancer - Category: Cancer & Oncology Authors: Tags: POSTERS B: Lifestyle, Prevention including Secondary Prevention Source Type: research
Molecules, Vol. 25, Pages 4490: Cicer arietinum L. Sprouts’ Influence on Mineralization of Saos-2 and Migration of MCF-7 Cells Molecules doi: 10.3390/molecules25194490 Authors: Małgorzata Zakłos-Szyda Ilona Gałązka-Czarnecka Joanna Grzelczyk Grażyna Budryn In the present study, we investigated the biological activity of four extracts obtained from Cicer arietinum L. sprouts. The fermentation of the sprouts with Lactobacillus casei and their incubation with β-glucosidase elevated the concentrations of isoflavonoids, especially coumestrol, formononetin and biochanin A. To study the biologica...
Source: Molecules - Category: Chemistry Authors: Tags: Article Source Type: research
Selective estrogen receptor modulators (SERMs) are an increasingly important therapeutic modality that are used by clinicians on a daily basis. Unfortunately, clinicians have a limited understanding regarding the underlying mechanism(s) of how SERMs function and their increasingly useful role in the treatment of estrogen-responsive target tissues such as the breast, bone, vagina, uterine endometrium, and brain. This review will provide a basic understanding of our current knowledge of SERM pharmacodynamics and will highlight the clinical applications of Food and Drug Administration–approved SERMs in the treatment of ...
Source: Menopause - Category: OBGYN Tags: Clinical Corner: Invited Review Source Type: research
ConclusionsOur study demonstrated that AA suppressed bone metastatic breast cancer. These findings indicate AA as a potential, novel curative drug candidate for patients with bone metastatic breast cancer.
Source: Cancer Medicine - Category: Cancer & Oncology Authors: Tags: ORIGINAL RESEARCH Source Type: research
This study is the first to provide a direct link between this inflammation and plaque development - by way of IFITM3. Scientists know that the production of IFITM3 starts in response to activation of the immune system by invading viruses and bacteria. These observations, combined with the new findings that IFITM3 directly contributes to plaque formation, suggest that viral and bacterial infections could increase the risk of Alzheimer's disease development. Indeed, researchers found that the level of IFITM3 in human brain samples correlated with levels of certain viral infections as well as with gamma-secretase activ...
Source: Fight Aging! - Category: Research Authors: Tags: Newsletters Source Type: blogs
Authors: Trifu SC, Istrate D, Miruna DA Abstract Schizophrenia is considered the most severe and debilitating psychiatric disorder. During the 80's, first reports on abnormalities of the schizophrenic brain which could be objectively observed on MRI, CT scans and other imagistic techniques were published. This showed that schizophrenia is a disorder that goes beyond the functional aspect of the symptomatology. The ties between psychiatry and endocrinology are easily observed, even empirically, by any mental health practitioner, and mirrored by endocrinology specialists. Disorders related to menstruation phase of th...
Source: Experimental and Therapeutic Medicine - Category: General Medicine Tags: Exp Ther Med Source Type: research
ConclusionThe 12-month exercise program prevented FN and TH bone loss in premenopausal breast cancer patients for 3  years. The bone-protective effect was reversible and lost thereafter.
Source: Osteoporosis International - Category: Orthopaedics Source Type: research
Socioeconomic status can help predict whether a person will die from heart...Read more on AuntMinnie.comRelated Reading: COVID-19 patients at risk for heart complications Cardiac CT shows promise for osteoporosis screening Breast cancer mortality higher after heart attack Echocardiography reveals heart changes in WNBA players DiA gets FDA nod, CE Mark for AI-based ultrasound tools
Source: AuntMinnie.com Headlines - Category: Radiology Source Type: news
Reports from the Women ’s Health Initiative (WHI), first published in 2002, have informed and complicated the narrative of the relative benefits and potential harms of menopausal hormone therapy (HT) over the past 20 years. Prior to the initiation of the WHI trials, hormone therapy had already experienced a tumultuous p ublic stature. Initially heralded as the cure for menopause in the 1960s, unopposed estrogen therapy was vilified when its association with increased risk of endometrial hyperplasia and cancer emerged. The discovery that the addition of progesterone to estrogen therapy mitigated this risk propelled ho...
Source: JAMA - Category: General Medicine Source Type: research
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