Association of VDR gene polymorphisms and 22  bp deletions in the promoter region of TLR2Δ22 (‐196‐174) with increased risk of pulmonary tuberculosis: A case‐control study in tea garden communities of Assam

Journal of Clinical Laboratory Analysis, EarlyView.
Source: Journal of Clinical Laboratory Analysis - Category: Laboratory Medicine Authors: Source Type: research

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Abstract OBJECTIVE: To report the spectrum of ethambutol induced optic neuropathy in a group of renal patients with tuberculosis and the role of visual evoked response (VER) in evaluating this disorder. METHODS: Twenty-three renal patients who were started on ethambutol as a part of anti-tubercular treatment for tuberculosis in India, were divided into 4 groups based on glomerular filtration rate (GFR): group 1-chronic kidney disease (CKD) with GFR 30 ≤ 60 mL/min; and group 4-GFR> 60
Source: Canadian Journal of Ophthalmology - Category: Opthalmology Authors: Tags: Can J Ophthalmol Source Type: research
With the development of rejuvenation therapies underway, and accelerating, somewhere ahead lies a dividing line. Some people will be the last to age to death, too comprehensively damaged for the technologies of the time to recover. Everyone else will live indefinitely in youth and health, protected from aging by periodic repair of the underlying cell and tissue damage that causes dysfunction and disease. Where is that dividing line? No one can say in certainty. I look at the children of today, with long lives ahead of them, and find it hard to believe that in a hundred years the problem won't be solved well in time for the...
Source: Fight Aging! - Category: Research Authors: Tags: Of Interest Source Type: blogs
Publication date: Available online 22 May 2019Source: Biochimica et Biophysica Acta (BBA) - Proteins and ProteomicsAuthor(s): Abyson Joseph, Valakunja Nagaraja, Ramanathan NateshAbstractGre factors reactivate stalled elongation complexes by enhancing the intrinsic transcript cleavage activity of RNA polymerase. Previous work by us has shown that unlike in Escherichia coli (E.coli), Mycobacterium tuberculosis Gre factor is essential for its survival. Apart from their role in transcription regulation Gre factors have been implicated in stress response. A recent study has shown the role of E.coli GreA as a cellular chaperone,...
Source: Biochimica et Biophysica Acta (BBA) Proteins and Proteomics - Category: Biochemistry Source Type: research
Publication date: June 2019Source: The Lancet Respiratory Medicine, Volume 7, Issue 6Author(s): The Lancet Respiratory Medicine
Source: The Lancet Respiratory Medicine - Category: Respiratory Medicine Source Type: research
Conditions:   Pulmonary Tuberculosis;   Other Specified Pulmonary Tuberculosis Interventions:   Drug: Sutezolid;   Drug: Bedaquiline, Delamanid, Moxifloxacin;   Drug: Midazolam oral solution Sponsors:   Michael Hoelscher;   European and Developing Countries Clinical Trials Partnership (EDCTP);   Sequella, Inc.;   Radboud University;   University of California, San Francisco;   German Federal Ministry of Education and Research Not yet recruiting
Source: ClinicalTrials.gov - Category: Research Source Type: clinical trials
Publication date: Available online 21 May 2019Source: Gynecologic Oncology ReportsAuthor(s): Ava Runge, Megan Bernstein, Alexa Lucas, Krishnansu S. TewariAbstractCervical cancer is the most common cancer in Tanzania. After excluding human immunodeficiency virus, lower respiratory infections, malaria, diarrheal diseases, and tuberculosis, cervical cancer kills more women than any other form of illness in the country. Unfortunately, Tanzania has a low doctor-to-patient ratio (1:50,000) and nearly 7000 women die each year from this disease. The clinical problem is further magnified by the country's lack of resources and preva...
Source: Gynecologic Oncology Reports - Category: OBGYN Source Type: research
Publication date: 21 May 2019Source: Cell Reports, Volume 27, Issue 8Author(s): Katherine J. Wu, Cara C. Boutte, Thomas R. Ioerger, Eric J. RubinSummaryMycobacterium tuberculosis, the causative agent of tuberculosis, withstands diverse environmental stresses in the host. The periplasmic protease HtrA is required only to survive extreme conditions in most bacteria but is predicted to be essential for normal growth in mycobacteria. We confirm that HtrA is indeed essential in Mycobacterium smegmatis and interacts with another essential protein of unknown function, LppZ. However, the loss of any of three unlinked genes, i...
Source: Cell Reports - Category: Cytology Source Type: research
ConclusionWhole-Genome Sequencing ofMycobacterium tuberculosis offers the detection of drug resistance to all drugs in a single test and also provides insight into the evolution and drug-resistant tuberculosis.
Source: Journal of Global Antimicrobial Resistance - Category: Infectious Diseases Source Type: research
Publication date: August 2019Source: Biomedicine &Pharmacotherapy, Volume 116Author(s): Wen-Jing Yi, Yu-Shuai Han, Li-Liang Wei, Li-Ying Shi, Huai Huang, Ting-Ting Jiang, Zhi-Bin Li, Jing Chen, Yu-Ting Hu, Hui-Hui Tu, Ji-Cheng LiAbstractLack of laboratory standards for cured tuberculosis (TB) can lead to early discharge of untreated TB patients from the hospital, resulting in increased risk of TB spread and of developing drug resistant Mycobacterium tuberculosis (Mtb). We used ultra-high performance liquid chromatography coupled with mass spectrometry (LC–MS) to detect heparin anticoagulant in plasma of untreated...
Source: Biomedicine and Pharmacotherapy - Category: Drugs & Pharmacology Source Type: research
AbstractTwo global epidemics, diabetes mellitus (DM) and tuberculosis (TB), have converged making their control even more challenging. We herein have reviewed metformin ’s (MTF) effect on patients with active and latent TB, as well as discussed its newly discovered biological mechanisms in mycobacteria. Mounting evidence suggests that MTF provides better outcomes in TB patients, especially those with DM. The mechanisms by which MTF produces its benefits are multi ple. Though metformin’s potential has been proven in patients with DM, larger and more thorough clinical trials, in DM and non-DM-TB patients, need to...
Source: Infection - Category: Infectious Diseases Source Type: research
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