UR Medicine Offers Free Skin Cancer Screening May 12

UR Medicine ’s Department of Dermatology is joining forces with the American Academy of Dermatology and the Rochester Dermatologic Society to provide free skin cancer screenings 9 a.m. to noon Saturday, May 12, at Strong Memorial Hospital in the Dermatology Suite on the second floor of the Ambulatory Care Fac ility.
Source: University of Rochester Medical Center Press Releases - Category: Universities & Medical Training Authors: Source Type: news

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In this study, we screened a siRNA library targeting 6024 human genes and identified Ku80 as a potential therapeutic target in melanoma cells. Knockdown of Ku80 significantly suppressed melanoma cell proliferation and induced apoptosis, as well as enhanced the antitumor effect of melatonin in melanoma in vitro and in vivo. Overexpression of Ku80, however, promoted melanoma growth and increased the insensitivity of melanoma cells to melatonin. Mechanistically, we found that Ku80 bound to the PDK1 promoter and activated the transcription of PDK1. Moreover, we showed that the binding of Ku80 at the PDK-1 promoter was HIF1-&al...
Source: Redox Biology - Category: Biology Source Type: research
Conclusion: Positive and negative predictive value of cytology was 95.3% and it was even 100% for well to moderately differentiated tumors. There was a tendency to sub-classify poorly differentiated SqCC as AC. Papanicolaou stain increased the diagnostic accuracy of SqCC. The combined tumor rate was 4% and after recognizing a tumor component, the second component was missed if the slide examination was terminated prematurely.
Source: CytoJournal - Category: Pathology Authors: Source Type: research
ConclusionsThere is a mortality risk for patients with squamous cell carcinoma, but not for adenocarcinoma at HBH compared with LBH. Further analysis of unadjusted variables such as performance status, completion of therapy, and continuity of care, and others should be undertaken among safety-net hospitals with the goal of creating appropriate clinical pathways for care of esophageal cancer in vulnerable populations.
Source: The Annals of Thoracic Surgery - Category: Cardiovascular & Thoracic Surgery Source Type: research
This study aimed to used bioinformatics data to undertake an integrative analysis of long noncoding RNA (lncRNA), microRNA (miRNA) and mRNA expression to construct a ceRNA network in metastatic melanoma. Data from the Cancer Genome Atlas (TCGA), the Gene Ontology (GO) database, and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway were analyzed. There were 471 cases that included 103 primary solid tumors and 368 cases of metastatic melanoma that included transcriptome sequencing data (including lncRNA and mRNA); 452 cases had miRNA sequencing data. Analysis of chip data identified 85 6 mRNAs, 67 miRNAs, and 250 lncRNA...
Source: Medical Science Monitor - Category: Research Tags: Med Sci Monit Source Type: research
Conclusion: The data suggests that peripheral blood expression profiles could be used to monitor tobacco-induced HNSCC as well as the treatment response. PMID: 31002268 [PubMed - as supplied by publisher]
Source: Biomarkers - Category: Research Tags: Biomarkers Source Type: research
Effect of electrochemotherapy with betulinic acid or cisplatin on regulation of heat shock proteins in metastatic human carcinoma cells in vitro. Oncol Rep. 2019 Apr 08;: Authors: Mączyńska J, Choromańska A, Kutkowska J, Kotulska M, Zalewski M, Zalewski J, Kulbacka J, Saczko J Abstract Betulinic acid (BTA) is naturally occurring triterpene that has received interest as a novel therapeutic substance with cytotoxicity towards a number of cancer cell lines. Despite the wide spectrum of biological and pharmacological effects, its effect may be limited its lipophobic properties. Therefore, strategie...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
Single‑cell intratumoral stemness analysis reveals the involvement of cell cycle and DNA damage repair in two different types of esophageal cancer. Oncol Rep. 2019 Apr 15;: Authors: Wu H, Li Y, Hou Q, Zhou R, Li Z, Wu S, Yu J, Jiang M Abstract Intratumoral heterogeneity, particularly the potential cancer stemness of single cancer cells, has not yet been fully elucidated in human esophageal cancer. Single‑cell transcriptome sequencing of two types of esophageal adenocarcinoma (EAC) and two types of esophageal squamous cell carcinoma (ESCC) tissues was performed, and the intratumoral cancer stemness ...
Source: Oncology Reports - Category: Cancer & Oncology Tags: Oncol Rep Source Type: research
We report for the first time the differential expression of checkpoint molecules on CD4+ and CD8+ lymphocytes at a different stage of activation in the local environment of lung cancer. Moreover, the circulating T cells have a distinct expression of these receptors, which suggests their poor utility as biomarkers for immunotherapy.
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
Publication date: Available online 19 April 2019Source: Nitric OxideAuthor(s): Hugo P. Monteiro, Elaine G. Rodrigues, Adriana K.C. Amorim Reis, Luiz S. Longo, Fernando T. Ogata, Ana I.S. Moretti, Paulo E. da Costa, Ana C.S. Teodoro, Maytê S. Toledo, Arnold SternAbstractCancer development is closely related to chronic inflammation, which is associated with identifiable markers of tumor progression, such as uncontrolled cell proliferation, angiogenesis, genomic instability, chemotherapeutic resistance, and metastases. Redox processes mediated by reactive oxygen species (ROS) and nitric oxide (NO) within the inflammator...
Source: Nitric Oxide - Category: Chemistry Source Type: research
CONCLUSIONS: Re-excision of skin cancer, below-knee excisions, and intraoperative hemorrhagic complications were predictive for infection in more than one study. More high-quality studies are required to accurately identify risk factors so they can be reliably used in clinical guidelines.
Source: Advances in Skin and Wound Care - Category: Dermatology Tags: FEATURES: LITERATURE REVIEW Source Type: research
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