Inspire Medical prices up-sized $108m IPO

Inspire Medical Systems yesterday up-sized its initial public offering to $108 million, or some $124 million if the underwriters option is exercised in full. Maple Grove, Minn.-based Inspire, which spun out from Medtronic (NYSE:MDT) in 2007, makes devices for treating obstructive sleep apnea. The company had said it planned to issue 5 million shares at $14 to $16 apiece, which would have fetched $75 million at the midpoint. But in a regulatory filing yesterday, Inspire said it sold 6.75 million shares at $16 apiece and put an underwriters option on the table that’s worth another $16.2 million. Inspire, which posted net losses of -$17.5 million on sales of $28.6 million last year, plans to list on the New York Stock Exchange under the INSP symbol. The flotation is slated to price next week. The company developed a pacemaker-like system designed to stimulate nerves to keep airways open during sleep to treat obstructive sleep apnea. BofA Merrill Lynch and Goldman Sachs &Co are acting as underwriters for the offering, according to an SEC filing. In November 2016, Inspire Medical closed a $37.5 million Series F round. The post Inspire Medical prices up-sized $108m IPO appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Funding Roundup Initial Public Offering (IPO) Neuromodulation/Neurostimulation Respiratory Wall Street Beat Inspire Medical Systems Inc. Source Type: news

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ConclusionsThe SASS alone has acceptable reliability and validity, but limited predictive values. A new tool, combining the SASS and other patient characteristics (i.e., age, BMI, and bedpartner-reported snoring and breathing pauses), demonstrated improved sensitivity and specificity, and thus may have greater utility in clinical practice for predicting OSA in pregnant women.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
AbstractRapid eye movement (REM) sleep was discovered nearly 60  years ago. This stage of sleep accounts for approximately a quarter of total sleep time in healthy adults, and it is mostly concentrated in the second half of the sleep period. The majority of research on REM sleep has focused on neurocognition. More recently, however, there has been a growing int erest in understanding whether obstructive sleep apnea (OSA) during the two main stages of sleep (REM and non-REM sleep) leads to different cardiometabolic and neurocognitive risk. In this review, we discuss the growing evidence indicating that OSA during REM s...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Patients suffering obstructive sleep apnea are mainly treated with continuous positive airway pressure (CPAP). Although it is a highly effective treatment, compliance with this therapy is problematic to achiev...
Source: BMC Medical Informatics and Decision Making - Category: Information Technology Authors: Tags: Research article Source Type: research
This article focuses on clinical examination to assist in maintaining stable function between jaw posture, muscle function, and temporomandibular joint stability. It describes a simple and understandable approach for assessment and management of common temporomandibular symptoms arising as side effects from use of mandibular advancement device therapy for obstructive sleep apnea. Follow-up visits are necessary to assess efficacy of sleep oral devices. An interdisciplinary approach is necessary for better treatment outcome. Qualified dentists offering this therapy should be educated and gain knowledge about diagnosis, preve...
Source: Sleep Medicine Clinics - Category: Sleep Medicine Authors: Source Type: research
Cardiology 2018;140:254 –256
Source: Cardiology - Category: Cardiology Source Type: research
(American Thoracic Society) A new guideline focused on the role of weight management in treating adult obstructive sleep apnea (OSA) has been published online by the American Thoracic Society in the Sept. 15 American Journal of Respiratory and Critical Care Medicine.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
The aim of this study was to determine whether specific perinatal factors are associated with obstructive sleep apnea syndrome (OSAS) in children.
Source: Sleep Medicine - Category: Sleep Medicine Authors: Tags: Original Article Source Type: research
CONCLUSIONS: Isolated EU was found to be associated with snoring, an elongated uvula and having suffered from previous episodes of EU. Associations among groups of EU patients and gender, obesity, smoking, alcohol consumption, personal and family atopy or obstructive sleep apnea, were not demonstrated. Allergy to A. simplex was the most commonly recorded cause. PMID: 30222112 [PubMed - as supplied by publisher]
Source: Journal of Investigational Allergology and Clinical Immunology - Category: Allergy & Immunology Authors: Tags: J Investig Allergol Clin Immunol Source Type: research
PMID: 30216279 [PubMed - in process]
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Test your medicine knowledge with the MKSAP challenge, in partnership with the American College of Physicians. A 52-year-old man is evaluated in follow-up after being diagnosed with severe obstructive sleep apnea 8 weeks ago. Continuous positive airway pressure (CPAP) was prescribed based on a titration during in-laboratory polysomnography. He notes some improvement in his sleep with CPAP, but he still feels drowsy during the day. He does not have problems with nasal congestion. Medical history is otherwise negative and he takes no medications. On physical examination, temperature is 37.2 °C (99.0 °F), bl...
Source: Kevin, M.D. - Medical Weblog - Category: General Medicine Authors: Tags: Conditions Pulmonology Source Type: blogs
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