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Inspire Medical prices up-sized $108m IPO

Inspire Medical Systems yesterday up-sized its initial public offering to $108 million, or some $124 million if the underwriters option is exercised in full. Maple Grove, Minn.-based Inspire, which spun out from Medtronic (NYSE:MDT) in 2007, makes devices for treating obstructive sleep apnea. The company had said it planned to issue 5 million shares at $14 to $16 apiece, which would have fetched $75 million at the midpoint. But in a regulatory filing yesterday, Inspire said it sold 6.75 million shares at $16 apiece and put an underwriters option on the table that’s worth another $16.2 million. Inspire, which posted net losses of -$17.5 million on sales of $28.6 million last year, plans to list on the New York Stock Exchange under the INSP symbol. The flotation is slated to price next week. The company developed a pacemaker-like system designed to stimulate nerves to keep airways open during sleep to treat obstructive sleep apnea. BofA Merrill Lynch and Goldman Sachs &Co are acting as underwriters for the offering, according to an SEC filing. In November 2016, Inspire Medical closed a $37.5 million Series F round. The post Inspire Medical prices up-sized $108m IPO appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Funding Roundup Initial Public Offering (IPO) Neuromodulation/Neurostimulation Respiratory Wall Street Beat Inspire Medical Systems Inc. Source Type: news

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OBJECTIVES: Traffic accidents associated with high mortality rate may produce serious problems especially in highways. Obstructive sleep apnea (OSA) has been associated with a high risk for traffic accidents due to excessive daytime sleepiness even in in-c...
Source: SafetyLit - Category: International Medicine & Public Health Tags: Distraction, Fatigue, Chronobiology, Vigilance, Workload Source Type: news
(American Thoracic Society) A drug used to treat excessive daytime sleepiness may not improve driving ability in adults with obstructive sleep apnea (OSA) who cannot tolerate standard therapies, according to new research published online in the American Journal of Respiratory and Critical Care Medicine.
Source: EurekAlert! - Medicine and Health - Category: International Medicine & Public Health Source Type: news
AbstractBackgroundRetropalatal region might be considered the most common site of obstruction in patients with snoring and OSA. We aimed at presentation of two combined techniques: modified anterior palatoplasty (MAP) and bilateral double suspension suture (DSS).MethodsThis prospective study was conducted on OSA patients with retro-palatal collapse only that was confirmed by nasoendoscopy during Muller ’s maneuver and drug induced sleep endoscopy. MAP and DSS were performed for all patients. Preoperative and 6 months after surgery, all patients underwent fiber-optic nasoendoscopy using the Muller maneuver and po...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Highly compliant tissue supporting the pharynx and low muscle tone enhance the possibility of upper airway occlusion in children with obstructive sleep apnea (OSA). The present study describes subject-specific computational modeling of flow-induced velopharyngeal narrowing in a female child with polycystic ovarian syndrome (PCOS) with OSA and a non-OSA control. Anatomically accurate three-dimensional geometries of the upper airway and soft-palate were reconstructed for both subjects using magnetic resonance (MR) images.
Source: Journal of Biomechanics - Category: Biomedical Science Authors: Source Type: research
WEDNESDAY, May 16, 2018 -- A high risk of obstructive sleep apnea (OSA) is common among older adults but is seldom investigated, though when it is investigated, it is almost always confirmed, according to a study published online May 9 in the...
Source: Drugs.com - Pharma News - Category: Pharmaceuticals Source Type: news
CONCLUSION: Patients seeking for positive airway pressure alternatives could not only benefit from reduction of AHI by TE-UPPP postoperatively; additionally, by changing the collapse pattern at the soft palate, they might also fulfill criteria for upper airway stimulation (UAS) in case of persistent OSA of at least moderate degree. PMID: 29766410 [PubMed - as supplied by publisher]
Source: Sleep and Breathing - Category: Sleep Medicine Authors: Tags: Sleep Breath Source Type: research
ConclusionThese results suggest that PAG can protect the myocardium against CIH-induced injury through inhibition of endoplasmic reticulum stress.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
ConclusionPatients seeking for positive airway pressure alternatives could not only benefit from reduction of AHI by TE-UPPP postoperatively; additionally, by changing the collapse pattern at the soft palate, they might also fulfill criteria for upper airway stimulation (UAS) in case of persistent OSA of at least moderate degree.
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
Conclusions: The Double Barrel Technique allows for a safe emergence from anesthesia in patients predisposed to upper airway obstruction (such as in obstructive sleep apnea and morbidly obese patients). To our knowledge, the Modified Double Barrel Technique is the first description for the use of nasal trumpets in patients who had nasal surgery and who have nasal splints in place. PMID: 29755518 [PubMed]
Source: Anesthesiology Research and Practice - Category: Anesthesiology Tags: Anesthesiol Res Pract Source Type: research
Conclusion: HTP (as a sole technique or as part of a multilevel intervention) could help with airway collapse and might be considered a safe, simple, and effective technique in the management of selected patients experiencing OSA. In addition, it seems to have no hazardous effect on either the voice or swallowing function of patients.Folia Phoniatr Logop 2017;69:271 –277
Source: Folia Phoniatrica et Logopaedica - Category: Speech-Language Pathology Source Type: research
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