Inspire Medical prices up-sized $108m IPO

Inspire Medical Systems yesterday up-sized its initial public offering to $108 million, or some $124 million if the underwriters option is exercised in full. Maple Grove, Minn.-based Inspire, which spun out from Medtronic (NYSE:MDT) in 2007, makes devices for treating obstructive sleep apnea. The company had said it planned to issue 5 million shares at $14 to $16 apiece, which would have fetched $75 million at the midpoint. But in a regulatory filing yesterday, Inspire said it sold 6.75 million shares at $16 apiece and put an underwriters option on the table that’s worth another $16.2 million. Inspire, which posted net losses of -$17.5 million on sales of $28.6 million last year, plans to list on the New York Stock Exchange under the INSP symbol. The flotation is slated to price next week. The company developed a pacemaker-like system designed to stimulate nerves to keep airways open during sleep to treat obstructive sleep apnea. BofA Merrill Lynch and Goldman Sachs &Co are acting as underwriters for the offering, according to an SEC filing. In November 2016, Inspire Medical closed a $37.5 million Series F round. The post Inspire Medical prices up-sized $108m IPO appeared first on MassDevice.
Source: Mass Device - Category: Medical Devices Authors: Tags: Funding Roundup Initial Public Offering (IPO) Neuromodulation/Neurostimulation Respiratory Wall Street Beat Inspire Medical Systems Inc. Source Type: news

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ConclusionIn a sample of male patients with mild-to-moderate obstructive sleep apnea, the optimal continuous positive airway pressure was predicted using the mandibular length, atlas–jaw distance and Mallampati classification.ResumoIntroduçãoA titulação manual é o padrão ouro para determinar a pressão ideal para o tratamento com a pressão positiva contínua nas vias aéreas; e a predição da pressão ideal é importante para evitar retardos na sua prescrição.ObjetivoVerificar se as avaliações cl&ia...
Source: Brazilian Journal of Otorhinolaryngology - Category: ENT & OMF Source Type: research
Conclusion: EDN-1 and TNF- α gene expression levels were associated with the occurrence of OSA.ORL 2019;81:16 –23
Source: ORL - Category: ENT & OMF Source Type: research
The results of multiple basic science and mechanistic clinical studies form a solid basis for a plausible pathophysiological link between obstructive sleep apnea (OSA) and atrial fibrillation (AF) [1]. In a meta-analysis of seven prospective cohort studies comprising 1087 patients, treatment of OSA by continuous positive airway pressure (CPAP) was associated with 40% reduction of AF recurrence after electrical cardioversion (ECV) or catheter ablation [2]. However, randomized controlled studies are lacking and this uncertainty is reflected by current international AF-guidelines, which recommend that it may be “reasona...
Source: International Journal of Cardiology - Category: Cardiology Authors: Tags: Editorial Source Type: research
ObjectiveThe aim of this study was to investigate the relationship between obstructive sleep apnea syndrome (OSAS) and lower urinary tract symptoms (LUTS) in patients with benign prostatic hyperplasia (BPH).MethodsThis multicenter study was performed on 122 male patients with dyspnea and/or sleep disorder. Patient characteristics were recorded. All patients underwent full ‐night polysomnography, and the apnea–hypopnea index (AHI) was calculated. LUTS were evaluated using the International Prostate Symptom Score (IPSS) and prostate volume was calculated by transabdominal ultrasonography. Based on the AHI, patients w...
Source: LUTS: Lower Urinary Tract Symptoms - Category: Urology & Nephrology Authors: Tags: ORIGINAL ARTICLE Source Type: research
AbstractObjectiveAirway inflammation plays an important role in obstructive sleep apnea (OSA); exhaled nitric oxide is regarded as a noninvasive marker of airway inflammation. The aim of this study was to evaluate fractional exhaled nitric oxide (FeNO) and nasal nitric oxide (nNO) in patients with OSA.MethodsSeventy-five patients with OSA and 30 health controls were enrolled in this study. FeNO and nNO were measured before and after sleep. Nasal lavage was performed in 31 non-smoking individuals immediately after NO measurement in the morning. The sample of nasal lavage was taken for cell classification and analyzing inter...
Source: Sleep and Breathing - Category: Respiratory Medicine Source Type: research
In this study, we sought to develop, implement, and evaluate the effectiveness of an electronic health record (EHR) alert to screen for OSA in patients with epilepsy. Methods A 3-month retrospective chart review was conducted of all patients with epilepsy>18 years of age who were evaluated in our epilepsy clinics prior to the intervention. An assessment for obstructive sleep apnea (AOSA) consisting of 12 recognized risk factors for OSA was subsequently developed and embedded in the EHR. The AOSA was utilized for a 3-month period. Patients identified with 2 or more risk factors were referred for polysomnography. A compa...
Source: Neurology Clinical Practice - Category: Neurology Authors: Tags: All Clinical Neurology, Sleep apnea, Electronic medical records, All Epilepsy/Seizures Research Source Type: research
Background: Obstructive sleep apnea (OSA) is a highly prevalent and consequential sleep disorder in older adults. Untreated moderate to severe OSA substantially increases the risk for hypertension and cardiovascular disease (CVD), which can be attributed to the accelerated progression of atherosclerosis and endothelial dysfunction. Objective: The aim of this study was to identify factors that can function as correlates of endothelial function in older adults with untreated, moderate to severe OSA and CVD or CVD risk factors. Methods: A subsample (N = 126) of adults aged 65 years and older from the HeartBEAT study w...
Source: Journal of Cardiovascular Nursing - Category: Nursing Tags: Feature Article/Online Only Source Type: research
Continuous positive airway pressure (CPAP) is the mainstay therapy for patients with obstructive sleep apnea (OSA) however compliance with CPAP is variable. Nasal ailments, such as nasal congestion are frequently mentioned as a cause for CPAP non-compliance, and potentially could be addressed prior to CPAP initiation, however, no specific criteria or recommendations for the evaluation and management of these patients exist. The aim of this retrospective study is to evaluate the effects of nasal anatomic features and disease on adherence to CPAP therapy for patients with OSA and determine the indications for pre-CPAP nasal ...
Source: Auris, Nasus, Larynx - Category: ENT & OMF Authors: Source Type: research
Authors: Cancienne JM, Brockmeier SF, Deasey MJ, Werner BC Abstract BACKGROUND: A few investigations exist which evaluate the influence of obstructive sleep apnea (OSA) on complications after arthroscopic rotator cuff repair. METHODS: A database was queried for patients undergoing rotator cuff repair with and without OSA and further subdivided into those with and without a billing code for a continuous positive airway pressure (CPAP) device. Thirty-day and 6-month adverse events were assessed. RESULTS: After regression analysis, patients with OSA had markedly increased emergency department visits and hospital admission (P
Source: The Journal of the American Academy of Orthopaedic Surgeons - Category: Orthopaedics Tags: J Am Acad Orthop Surg Source Type: research
Publication date: Available online 7 December 2018Source: NeuroscienceAuthor(s): Teresa Macheda, Kelly Roberts, Danielle N Lyons, Emma Higgins, Kyle J Ritter, Ai-ling Lin, Warren J. Alilain, Adam D. BachstetterAbstractSleep disturbances are a common early symptom of neurodegenerative diseases, including Alzheimer’s disease (AD) and other age-related dementias, and emerging evidence suggests that poor sleep may be an important contributor to development of amyloid pathology. Of the causes of sleep disturbances, it is estimated that 10% - 20% of adults in the United States have sleep-disordered breathing (SDB) disorder...
Source: Neuroscience - Category: Neuroscience Source Type: research
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