“Non-invasive Follicular Thyroid Neoplasm with Papillary like Nuclear Features”: An Institutional Retrospective Study with Re-nomenclature and Re-classification

AbstractThe cumulative efforts of pioneers in field of Thyroid pathology have resulted in proposed reclassification of Encapsulated Follicular Variant of Papillary Thyroid Carcinoma (EFVPTC) to “Non-invasive follicular thyroid neoplasm with papillary-like nuclear features” (NIFTWP) due to indolent clinical behaviour. To study the spectrum of EFVPTCs in our institute and to reclassify them as NIFTWP using stringent morphological criteria. This is a retrospective study conducted from Jan 2014 to July 2017. Institutional records were accessed and out of 485 thyroidectomy cases, 35 cases of EFVPTC were taken into study and field’s kappa was used as a means of statistical analysis. The study conducted on 35 cases of EFVPTCs using strict morphological criteria lead to re-nomenclature and re-classification of 30 out of these 35 cases, with a field’s kappa value of 4.3. The present study, lead to re-nomenclature and re-classification of 30 cases of EFVPTC to NIFTWP and proved statistically that there is moderate level of Inter-observer agreement regarding the criteria used for this re-nomenclature and re-classification.
Source: Indian Journal of Otolaryngology and Head and Neck Surgery - Category: ENT & OMF Source Type: research

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Authors: Ullmann TM, Gray KD, Limberg J, Stefanova D, Moore MD, Buicko JL, Finnerty BM, Zarnegar R, Fahey T, Beninato T Abstract Background Health insurance has been shown to be a key determinant in cancer care, but it is unknown to what extent insurance status affects treatments provided to papillary thyroid cancer (PTC) patients. We hypothesized that insured patients with papillary thyroid cancer would have lower-risk tumors at diagnosis and be more likely to receive adjuvant therapies at follow-up. Methods The American College of Surgeons' National Cancer Database was queried to identify all patients diagnosed w...
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
Multifocality in papillary thyroid carcinoma is common. The aim of this study is to determine whether patients with multifocal disease, treated with lobectomy alone, have an increased risk of contralateral lobe papillary thyroid carcinoma, regional recurrence, and poorer survival.
Source: Surgery - Category: Surgery Authors: Source Type: research
Current surgical management in RET mutation carriers [Aktualne postępowanie chirurgiczne u nosicieli mutacji proto-onkogenu RET]. Endokrynol Pol. 2019;70(4):367-379 Authors: Czarniecka A, Oczko-Wojciechowska M, Hajduk A, Zeman M, Jarzab B Abstract Medullary thyroid carcinoma (MTC) still remains a rare endocrine tumor. 20-25% of MTC cases are genetically determined. The detection of the RET proto-oncogene mutation in 1993 allowed to understand the unique genotype-phenotype relationships in hereditary medullary thyroid carcinoma (HMTC) and formed the basis for therapeutic decisions based on the molecul...
Source: Endokrynologia Polska - Category: Endocrinology Authors: Tags: Endokrynol Pol Source Type: research
AbstractRET proto-oncogene (RET) mutations were proved to be related to the development of medullary thyroid carcinoma (MTC). We aimed to analyze the role ofRET mutations in cervical lymph node metastasis in patients with MTC. Forty-nine patients with preoperatively diagnosed MTC by fine-needle aspiration cytology (FNAC) who underwent bilateral total thyroidectomy with cervical lymphadenectomy were included. PostoperativeRET gene test and pathological analysis were performed with the surgical specimens; serum calcitonin (Ctn) and carcinoembryonic antigen (CEA) levels were tested pre- and postoperatively, to evaluate the as...
Source: Endocrine Pathology - Category: Pathology Source Type: research
ConclusionIf postoperative RAI treatment is considered in low-risk DTC, any delay in RAI administration above 9  months since diagnosis may be related to poorer long-term outcomes.
Source: Nuclear Medicine and Molecular Imaging - Category: Nuclear Medicine Source Type: research
ABSTRACT The very rare thyroid-like carcinoma of the kidney (TLCK) is microscopically similar to thyroid follicular cell carcinoma (TFCC). Differential diagnosis with secondary thyroid tumors depends on non-reactivity to immunohistochemical (IHC) markers for TFCC (thyroglobulin - TG and TTF1). We herein describe the fourth Pediatric case in literature and extensively review the subject. Only 29 cases were published to the moment. Most cases were asymptomatic and incidentally detected. Most tumors are hyperechoic and hyperdense with low grade heterogenous enhancement on CT and MRI. Most patients were treated with radical ne...
Source: International Braz J Urol - Category: Urology & Nephrology Source Type: research
We report a unique case of differentiated thyroid carcinoma (DTC) with squamous metaplasia complicated with chronic discharging ulcer. A 76-year-old gentleman was referred to us after defaulted treatment 1  year post-total thyroidectomy. He presented to us with long-standing chronic, non-healing, ulcerative and discharging wound at the anterior neck at previous total thyroidectomy scar. The primary tumour was histologically diagnosed as papillary malignant cells with extensive squamous metaplasia. Sq uamous metaplasia is a rare finding in thyroid carcinoma that carried a poorer prognostic factor.
Source: Indian Journal of Surgical Oncology - Category: Cancer & Oncology Source Type: research
This study reviewed the medical records of 996 LLNs from 858 patients with suspicious thyroid nodules or after thyroidectomy from January 2013 to January 2016. All patients took US-FNA. The US characteristics and the malignancy rate of LLNs classified into group A and group B based on size were analyzed and compared (group A, ≥6 mm; group B, 0.005) in multiple regression analysis, whereas the malignancy rate in the large LLNs (286/425; 67.3%) was slightly higher than that in the small LLNs (338/571; 59.2%) (P = 0.01). However, no significant difference was observed between the groups in terms of calcification, absence o...
Source: Ultrasound Quarterly - Category: Radiology Tags: Original Research Source Type: research
CONCLUSIONS: Because of the association between FAP or colon cancer with multifocal CMV-PTC, we confirm that an analysis of APC gene mutation and colonoscopy should be carried-out in these patients when multiple thyroid tumors are found. PMID: 31469036 [PubMed - as supplied by publisher]
Source: Thyroid : official journal of the American Thyroid Association - Category: Endocrinology Tags: Thyroid Source Type: research
as Calò Differentiated thyroid carcinoma (DTC) is usually associated with a favorable prognosis. Nevertheless, up to 30% of patients present a local or distant recurrence. The aim of this study was to assess the incidence of recurrence after surgery for DTC and to identify predictive factors of recurrence. We included in this retrospective study 579 consecutive patients who underwent thyroidectomy for DTC from 2011 to 2016 at our institution. We observed biochemical or structural recurrent disease in 36 (6.2%) patients; five-year disease-free survival was 94.1%. On univariate analysis, male sex, histotype, ly...
Source: Cancers - Category: Cancer & Oncology Authors: Tags: Article Source Type: research
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