Involvement of acute neuroinflammation in postoperative delirium-like cognitive deficits in rats

ConclusionOur findings indicate that surgery-induced acute, transient, brain-wide neuroinflammation may be involved in the pathogenesis of the postoperative delirium-like cognitive deficits in rats. Furthermore, neuroinflammation may convert from acute to chronic in an age- and hippocampal-specific manner, likely resulting in the development of sustained cognitive dysfunction.

http://link.springer.com/10.1007/s00540-018-2504-x

Source: Journal of Anesthesia - May 3, 2018 Category: Anesthesiology Source Type: research