The norpurpureine alkaloid from Annona purpurea inhibits human platelet activation in vitro.

Conclusion: Norpurpureine displays a promising in vitro pharmacological profile as an inhibitor of human platelet activation. Its molecular target could be a common effector between Ca2+ and cAMP signaling, such as the PLC-PKC-Ca2+ pathway and PDEs. This needs further evaluation at the protein isoform level. PMID: 29713353 [PubMed - in process]

https://www.ncbi.nlm.nih.gov/pubmed/29713353?dopt=Abstract

Source: Cellular and Molecular Biology Letters - May 3, 2018 Category: Biochemistry Authors: Sánchez G, Estrada O, Acha G, Cardozo A, Peña F, Ruiz MC, Michelangeli F, Alvarado-Castillo C Tags: Cell Mol Biol Lett Source Type: research