Progressive Non-familial Adult onset Cerebellar Degeneration: An Unusual Occurrence with Hashimoto's Thyroiditis.

We report a case of cerebellar atrophy in a 31 year old female whose detailed evaluation had revealed sub-clinical hypothyroidism secondary to autoimmune thyroiditis with a very high anti-TPO (anti-thyroid peroxidase) antibody levels. MRI (Magnetic Resonanace Imaging) of brain showed diffuse bilateral cerebellar atrophy. She was treated with thyroid hormone supplementation and after one year of follow up, cerebellar signs had disappeared completely with significant reduction in anti-TPO antibody levels. Imaging of the brain post one year of follow-up revealed normal cerebellum. Hence, we opine that thyroid dysfunction should always be kept in mind while evaluating patients presenting with acute onset cerebellar ataxia as it can be easily reversed with thyroid hormone replacement therapy. PMID: 29713105 [PubMed - in process]
Source: Psychopharmacology Bulletin - Category: Psychiatry & Psychology Tags: Psychopharmacol Bull Source Type: research

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Authors: Soca-Chafre G, Hernández-Pedro N, Aviles-Salas A, Versón CA, Sánchez KC, Cardona AF, Avila-Moreno F, Barrios-Bernal P, Flores-Estrada D, Arrieta O Abstract Background: Wood smoke exposure (WSE) has been associated with an increased risk of lung cancer development. WSE has been related with high frequency of EGFR mutations and low frequency of KRAS mutations. The aim of this study was to evaluate large scale genomic alterations in lung adenocarcinomas associated with WSE using targeted next generation sequencing. Methods: DNA multi-targeted sequencing was performed in 42 fresh-froze...
Source: Oncotarget - Category: Cancer & Oncology Tags: Oncotarget Source Type: research
Authors: Li H, Min J, Mao X, Wang X, Yang Y, Chen Y Abstract Autoimmune thyroiditis is among the most prevalent of all the autoimmunities in population. It is characterized as both cellular immune responses with T, B cells infiltrating to the thyroid gland followed by hypothyroidism as a result of destruction of the thyroid follicles and fibrous replacement of the parenchymal tissue, as well as immune response for TPO and Tg-antibody production. Experimental autoimmune thyroiditis (EAT) has been proven to be an ideal model to study autoimmune thyroiditis. In the present study, we induced an EAT model in rats and ex...
Source: American Journal of Translational Research - Category: Research Tags: Am J Transl Res Source Type: research
In conclusion, immune-mediated hypophysitis is often irreversible. Fortunately, it can be managed adequately with hormone replacements. Further investigations are warranted to unveil underlying mechanisms and ethnic differences to guide the solutions.
Source: Journal of the Formosan Medical Association - Category: General Medicine Source Type: research
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Source: Autoimmunity Reviews - Category: Allergy & Immunology Source Type: research
ConclusionsDespite the effective struggle with iodine deficiency and salt iodination control program in Konya, we concluded that iodine deficiency still persists as a significant problem in pregnancies.
Source: Journal of Endocrinological Investigation - Category: Endocrinology Source Type: research
Conditions:   Leukoencephalopathies;   LBSL;   Leukoencephalopathy With Brainstem and Spinal Cord Involvement and Lactate Elevation;   White Matter Disease;   Ataxia, Cerebellar;   Genetic Disease Intervention:   Sponsor:   Hugo W. Moser Research Institute at Kennedy Krieger, Inc. Recruiting
Source: - Category: Research Source Type: clinical trials
Autoimmune disorders are a category of diseases in which the immune system attacks healthy cells as a result of a dysfunction of the acquired immune system. Clinical presentation and diagnosis are disease specific and often correspond with the degree of inflammation, as well as the systems involved. Treatment varies based on the specific disease, its stage of presentation, and patient symptoms. The primary goal of treatment is to decrease inflammation, minimize symptoms, and lessen the potential for relapse. Graves disease, Hashimoto thyroiditis, rheumatoid arthritis, Crohn disease, ulcerative colitis, systemic lupus eryth...
Source: Nursing Clinics of North America - Category: Nursing Authors: Source Type: research
Publication date: Available online 9 August 2018Source: NeuroImageAuthor(s): Aaron Carass, Jennifer L. Cuzzocreo, Shuo Han, Carlos R. Hernandez-Castillo, Paul E. Rasser, Melanie Ganz, Vincent Beliveau, Jose Dolz, Ismail Ben Ayed, Christian Desrosiers, Benjamin Thyreau, José E. Romero, Pierrick Coupé, José V. Manjón, Vladimir S. Fonov, D. Louis Collins, Sarah H. Ying, Chiadi U. Onyike, Deana Crocetti, Bennett A. LandmanAbstractThe human cerebellum plays an essential role in motor control, is involved in cognitive function (i.e., attention, working memory, and language), and helps to regulate emot...
Source: NeuroImage - Category: Neuroscience Source Type: research
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