Haemoglobin A1c or Glycated Albumin for Diagnosis and Monitoring Diabetes: An African Perspective

AbstractDiabetes mellitus (DM) has reached epidemic proportions across the globe with the largest increases seen in sub-Saharan Africa. Those that are diagnosed are largely poorly controlled. This review summarizes the limitations of the use of glycated haemoglobin (HBA1c) in Africa and current knowledge on the utility of glycated albumin and fructosamine in African patients. The diagnosis and monitoring of DM in African patients may be compromised by associated conditions like sickle cell anaemia, chronic kidney disease and HIV infection. Glycated albumin reflects short term glycaemia and is not affected by many conditions that alter HbA1c. It can be measured enzymatically, and this review discusses methods for analysis, and discusses the advantages and limitations in specific situations with an emphasis on conditions that also affect HbA1c.
Source: Indian Journal of Clinical Biochemistry - Category: Biochemistry Source Type: research

Related Links:

CONCLUSIONS: The present study suggests that about 8.24% of resident doctors have Problematic internet use/IA. Problematic internet use/IA is associated with presence of higher level of depressive symptoms, perceived stress and burn out. Further, Problematic internet use/IA is also associated with higher likelihood of facing violence in the hands of patients and their caregivers. PMID: 30529568 [PubMed - as supplied by publisher]
Source: Asian Journal of Psychiatry - Category: Psychiatry Tags: Asian J Psychiatr Source Type: research
Authors: Wu Y, Jia K, Wu H, Sang A, Wang L, Shi L, Jiang K, Dong J Abstract Diabetic retinopathy (DR) is a severe microvascular complication of diabetes and the primary cause of vision loss in diabetic patients. Previous research has revealed that long non‑coding RNAs (lncRNAs) and microRNAs (miRNAs) play pivotal roles in the pathogenesis of DR. However, the roles of lncRNA‑miRNA‑mRNA interactions in DR are poorly understood. In the present study, we aimed to compute a global triple network of competitive endogenous RNAs (ceRNAs) in order to pinpoint essential molecules. We found that there were 802 ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
Melatonin attenuates renal fibrosis in diabetic mice by activating the AMPK/PGC1α signaling pathway and rescuing mitochondrial function. Mol Med Rep. 2018 Nov 29;: Authors: Li J, Li N, Yan S, Lu Y, Miao X, Gu Z, Shao Y Abstract Mitochondrial homeostasis is a highly regulated process that serves a critical role in the maintenance of renal structure and function. The growing interest in the field of mitochondrial homeostasis promises to provide more information regarding the mechanisms involved in diabetic renal fibrosis, and aid in the development of novel strategies to combat the disease. In the ...
Source: Molecular Medicine Reports - Category: Molecular Biology Tags: Mol Med Rep Source Type: research
TYPE 2 DIABETES symptoms may not be obvious for many years and can be mistaken for less serious conditions. But recognising all the warning signs is very important because left untreated, life-threatening complications can occur. One sign to be wary of can be evident in your urine.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
Conclusions: This is the largest cohort of HPeV3 cases with clinical data and pediatrician-assessed neurodevelopmental follow-up to date. Developmental concerns were identified in 11 children at early follow-up. Abnormal magnetic resonance imaging during acute infection did not specifically predict poor neurodevelopmental in short-term follow-up. Continued follow-up of infants and further imaging correlation is needed to explore predictors of long-term morbidity.
Source: The Pediatric Infectious Disease Journal - Category: Infectious Diseases Tags: Original Studies Source Type: research
TYPE 2 DIABETES symptoms may not be obvious for many years and can be mistaken for less serious conditions. But recognising all the warning signs is very important because left untreated, life-threatening complications can occur. One sign to be wary of can be evident in your urine.
Source: Daily Express - Health - Category: Consumer Health News Source Type: news
As an observer, it can be difficult to find out what ’s happening with value-based contracts (VBCs). The fanfare that accompanies the announcement of a deal invariably gives way to a long period of silence, a good sign if you subscribe to the mantra that no news is good news, but if you don’t, there is cause for concern.The smattering of reports on the topic suggest that green shoots are emerging. A recent survey of 120 payers conducted by the ORC International and commissioned by Change Healthcare, found that payers reported an average saving in medical costs of 5.6% from VBC strategies with an accompanying 77...
Source: EyeForPharma - Category: Pharmaceuticals Authors: Source Type: news
Indivior Plc said on Wednesday a U.S. court ruling had put a hold on Indian rival Dr. Reddy's Laboratories launching a generic competitor to the London-listed drugmaker's bestselling opioid addiction treatment.
Source: Reuters: Health - Category: Consumer Health News Tags: healthNews Source Type: news
by Craig Klugman, PhD Jump to The Good Doctor (Season 2; Episode 10): Epidemic &Virtue Ethics; Jump to Chicago Med (Season 4; Episode 9): Not following patient wishes The Good Doctor (Season 2; Episode 10): Epidemic &Virtue Ethics This episode revolves around an unidentified pathogen invading the ED when two patients are brought in immediately after their flight from Malaysia lands. Both of them die and the ED is quarantined: All ambulances are diverted and walk-ins are sent away.…
Source: blog.bioethics.net - Category: Medical Ethics Authors: Tags: BioethicsTV Decision making End of Life Care Featured Posts Informed Consent Public Health Source Type: blogs
The national health impact could be substantial, preventing more than 190,000 cases of diabetes and 16,000 cases of cancerWe don ’t often equate the kilojoules we drink in our glass of wine or pint of beer with the weight that accumulates around our middle. Butour new study shows increasing the price of alcohol is the foremost value-for-money policy option to prevent obesity in Australia.The study, released today, shows if we increase alcohol taxes by standardising them across different types of alcohol, overall alcohol consumption would go down. This would lead to substantial reductions in the kilojoules Australians...
Source: Guardian Unlimited Science - Category: Science Authors: Tags: Health Alcohol Tax Obesity Australia news Business (Australia) Medical research Source Type: news
More News: African Health | Anemia | Biochemistry | Chronic Kidney Disease | Diabetes | Endocrinology | Epidemics | Epidemiology | India Health | Sickle Cell Anemia | Urology & Nephrology