(OA28) Habitat Analysis of DCE-MRI Predicts for Response to Neoadjuvant Chemotherapy in Breast Cancer

Dynamic Contrast Enhanced (DCE-) MRI can characterize the microenvironment in solid tumors by determining areas of inadequate or heterogeneous perfusion with hyper-permeable vasculature. As tumor oxygenation is dependent on the microcirculation, the technique may be useful to identify tumor areas with poor blood flow, and therefore, hypoxic microenvironments. Many studies have evaluated DCE-MRI for prediction of breast tumor ’s response to neoadjuvant chemotherapy. However, the analysis has been focused on the entire tumor volume and not accounting for tumor heterogeneity.
Source: International Journal of Radiation Oncology * Biology * Physics - Category: Radiology Authors: Tags: Oral Abstract Source Type: research