Gremlin activates the Notch pathway linked to renal inflammation

In conclusion, Gremlin activates the Notch pathway in the kidney and this is linked to NF-kB-mediated inflammation, supporting the hypothesis that Notch inhibition could be a potential anti-inflammatory strategy for renal diseases.

Source: Clinical Science - May 2, 2018 Category: Biomedical Science Authors: Lavoz, C., Poveda, J., Marquez-Exposito, L., Rayego-Mateos, S., Rodrigues-Diez, R. R., Ortiz, A., Egido, J., Mezzano, S., Ruiz-Ortega, M. Tags: PublishAheadOfPrint Source Type: research