Effect of running exercise on the number of the neurons in the hippocampus of young transgenic APP/PS1 mice.

Effect of running exercise on the number of the neurons in the hippocampus of young transgenic APP/PS1 mice. Brain Res. 2018 Apr 28;: Authors: Jiang L, Ma J, Zhang Y, Zhou CN, Zhang L, Chao FL, Chen LM, Jiang R, Wu H, Tang Y Abstract To investigate the effect of running exercise on the number of the neurons in the hippocampus of young APP/PS1mice, twenty 6-month-old male APP/ PS1 transgenic mice were randomly divided into the APP/PS1 control (AD control) group and the APP/PS1 running (AD running) group (10 mice per group), and ten wild-type mice of the littermate were regarded as the wild-type (WT) group. The AD running mice ran on motorized treadmill machiene for 4 months, while the WT mice and AD control mice were housed in standard condition without running. Then, Morris water maze tests (MWM) were used to assess the special learning and memory abilities of mice in three groups. The stereological methods were used to quantitatively evaluate the volume of the hippocampus, CA1/2, CA3 and the dentate gyrus (DG) and count the number of the neurons in CA1/2, CA3 and DG. We found that 4-month running effectively shortened the escape latency of young APP/PS1 control mice in MWM. More importantly, 4-month running effectively increased the volumes of the hippocampus, CA1/2, CA3 and DG and increased the number of neurons in CA1/2, CA3 and DG in young APP/PS1 mice. The present results suggested that 4-month running has significant beneficial...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research