ERK activation is required for the antiepileptogenic effect of low frequency electrical stimulation in kindled rats.

CONCLUSION: Obtained results showed ERK signaling pathway had important role in mediating the antiepileptogenic effect of LFS in perforant path kindling. These findings represent a promising opportunity to gain insight about LFS mechanism in epilepsy therapy.
PMID: 29705048 [PubMed - as supplied by publisher]

Source: Brain Research Bulletin - April 26, 2018 Category: Neurology Authors: Mardani P, Oryan S, Sarihi A, Komaki A, Shojaei A, Dehghan S, Mirnajafi-Zadeh J Tags: Brain Res Bull Source Type: research