A multicenter study of clinical presentations and predictive factors for severe manifestation of dengue in adults.

A multicenter study of clinical presentations and predictive factors for severe manifestation of dengue in adults. Jpn J Infect Dis. 2018 Apr 27;: Authors: Temprasertrudee S, Thanachartwet V, Desakorn V, Keatkla J, Chantratita W, Kiertiburanakul S Abstract Severe dengue is more prevalent in adults than in children. Our objectives were to determine the clinical presentations of dengue in adults and to identify predictive factors for severe dengue. A retrospective cohort study was performed in adults with dengue, as confirmed by positive NS1 antigen. Patients were classified into non-severe and severe dengue. A total of 357 patients were enrolled; 45.4% were male, with median (interquartile range, IQR) age of 27.9 (21.8-43.5) years. In all, 28.3% of patients had warning signs and 10.6% of patients had severe dengue. Patients with severe dengue had significantly older age [35.1 (26.2-50.6) vs. 26.7 (21.7-43.3) years, P=0.010], higher prevalence of immunocompromised condition (7.9% vs. 0.9%, P=0.018), cough (29% vs. 16%, P=0.046), hepatomegaly (10.5% vs. 3.1%, P=0.050), impaired consciousness (5.3% vs. 0%, P=0.011) and median (IQR) alanine aminotransferase (ALT) [151 (57-295) vs. 66 (37-114) U/L, P=0.008]. By multivariate analysis, having cough (odds ratio [OR] 8.07; 95% confidence interval [CI] 2.51-30.16, P=0.001) and ALT >120 U/L (OR 3.51; 95% CI 1.11-11.14, P=0.033) were predictors of severe dengue. Early recognition of some risk ...
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research