The development of a novel diagnostic assay that uses a pseudotyped vesicular stomatitis virus for the detection of neutralising activity to Crimean-Congo haemorrhagic fever virus.

The development of a novel diagnostic assay that uses a pseudotyped vesicular stomatitis virus for the detection of neutralising activity to Crimean-Congo haemorrhagic fever virus.
Jpn J Infect Dis. 2018 Apr 27;:
Authors: Suda Y, Chamberlain J, Dowall S, Saijo M, Horimoto T, Hewson R, Shimojima M
Abstract
Crimean-Congo haemorrhagic fever virus is a risk group 4 pathogen, which mandates the use of maximum containment facilities, often called biosafety level 4 (BSL-4) or containment level 4 (CL-4) laboratories when working with infectious materials. Diagnostic and research work involving live viruses in such laboratories is time-consuming and awkward resulting in delays. We herein show that the serum neutralising activity against the virus can be measured in low-containment laboratories using a pseudotyped virus.
PMID: 29709967 [PubMed - as supplied by publisher]

Source: Japanese Journal of Infectious Diseases - April 27, 2018 Category: Infectious Diseases Authors: Suda Y, Chamberlain J, Dowall S, Saijo M, Horimoto T, Hewson R, Shimojima M Tags: Jpn J Infect Dis Source Type: research