Analysis of HPeV genotype in Yokohama district from 2000-2016.

Analysis of HPeV genotype in Yokohama district from 2000-2016. Jpn J Infect Dis. 2018 Apr 27;: Authors: Momoki TS Abstract Human parechovirus (HPeV) infections in Yokohama City, Japan, were surveyed from 2000 to 2016. The sequence of the VP1 region of HPeV was used to construct a phylogenetic tree and to reveal the putative amino acid (aa) sequences. The phylogenetic analysis showed the presence of three genotypes in Yokohama City: HPeV1 (25 specimens), HPeV3 (86 specimens), and HPeV4 (2 specimens). HPeV1 was detected nearly every year, with the highest number detected in 2014. HPeV3 was not detected until 2005 but detected during a 3-year period thereafter. HPeV1 was most prevalent from July to November, whereas HPeV3 peaked in July and August. HPeV1 was mainly detected in patients with infectious gastroenteritis or respiratory tract infections. In contrast, 87% of HPeV3-positive cases were patients under 2 months of age with a viral-induced fever. An analysis of the aa sequence of VP1 revealed a divergence within the same HPeV genotype, which was useful in analyzing the emergence and re-emergence of HPeV during the survey period. These findings suggest that the molecular analysis of HPeV may contribute to a better understanding of its epidemiology. PMID: 29709970 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Tags: Jpn J Infect Dis Source Type: research