The Protobothrops flavoviridis hemorrhagic metalloproteinase HR2 is inhibited by human alpha 2-macroglobulin.
In this study, we investigated the interaction between the hemorrhagic metalloproteinases HR1 and HR2 from habu venom and human α2-macroglobulin. Hemorrhagic activity of HR2 was completely inhibited by human α2-macroglobulin. However, the hemorrhagic activity of the large molecule HR1a was not inhibited. Size exclusion chromatography revealed that human α2-macroglobulin captured the HR2 molecule and formed a complex with it, thus inhibiting hemorrhagic activity. These results suggest that human α2-macroglobulin plays an important role in the inhibition of hemorrhage induced by HR2 from habu venom.
PMID: 29709984 [PubMed - as supplied by publisher]
Source: Japanese Journal of Infectious Diseases - Category: Infectious Diseases Authors: Morine N, Matsuda S, Izumi Y, Oshiro A, Kudaka J Tags: Jpn J Infect Dis Source Type: research