Research Progress of Progesterone Preparations: a mini Review.

CONCLUSION: Although progesterone has first-pass effects, with these methods, the bioavailability and compliance can greatly increase. PMID: 29708071 [PubMed - as supplied by publisher]
Source: Current Drug Metabolism - Category: Drugs & Pharmacology Authors: Tags: Curr Drug Metab Source Type: research

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The objective of this study was to compare the performance of screening mammography versus magnetic resonance imaging (MRI) in hormone replacement therapy (HRT) users.MethodsWe performed a retrospective review of 4628 women who had mammography or breast MRI screening from the beginning of HRT use at three institutions from April 2005 to December 2015. Information of demographics, number of biopsies performed and pathologic outcomes were collected. Sensitivity, specificity, negative predictive value (NPV) and positive predictive value (PPV) of screening mammography and MRI were compared.ResultsTotally 11,540 screening studi...
Source: European Journal of Medical Research - Category: Research Source Type: research
You may have heard melasma referred to as “the mask of pregnancy,” because it is sometimes triggered by an increase in hormones in pregnant women. But while the condition may be common among pregnant women, you don’t have to be pregnant to experience melasma. “It’s not only associated with pregnancy, but can affect women at all stages of life,” says Dr. Shadi Kourosh, director of the Pigmentary Disorder and Multi-Ethnic Skin Clinic at Harvard-affiliated Massachusetts General Hospital. And it may last for many years. “Women who develop melasma in their teens or 20s or 30s may see it...
Source: Harvard Health Blog - Category: Consumer Health News Authors: Tags: Health Pregnancy Skin and Hair Care Source Type: blogs
18 October 2018   is World Menopause Day and October is World Menopause Month.Cochrane Gynaecology and Fertility Group has published multiple reviews assessing the effectiveness and safety of interventions in menopausal women, including peri and postmenopausal women. To celebrate World Menopause Day we have collated a special selection of reviews investigating various treatments  for menopausal symptoms such as hormone therapy, tibolone, relaxation, exercise, and alternative therapy.Black cohosh (Cimicifuga spp.) for menopausal symptomsDehydroepiandrosterone for women in the peri- or postmenopausal phaseHormone t...
Source: Cochrane News and Events - Category: Information Technology Authors: Source Type: news
Abstract Neurological diseases such as ischemic stroke can be debilitating and have limited treatments available. The progestin Nestorone® (segesterone acetate) has been evaluated for use in birth control and hormone replacement therapy due to its potency and high affinity for the progesterone receptor. Interestingly, Nestorone also exerts neuroprotection in animals afflicted with various central nervous system diseases, including stroke, which implicates its potential for treating these maladies in clinical settings. In fact, a recent Brain Research paper by Tanaka and colleagues demonstrates Nestorone's abil...
Source: Brain Research - Category: Neurology Authors: Tags: Brain Res Source Type: research
Horm Metab Res 2018; 50: 738-746 DOI: 10.1055/a-0741-8300Bisphosphonates, such as alendronate, have become the most widely used and effective anti-resorptive therapy for postmenopausal osteoporosis. Previous genetic studies suggest that ethnicity may drive differing responses to bisphosphonate therapy in East Asians and non-East Asians. Therefore, the aim of this study was to comparatively evaluate the efficacy of alendronate upon lumbar spinal BMD and vertebral fracture rates in East Asians and non-East Asians with postmenopausal osteoporosis. MEDLINE, EMBASE, and Cochrane CENTRAL were searched for relevant randomized con...
Source: Hormone and Metabolic Research - Category: Endocrinology Authors: Tags: Endocrine Care Source Type: research
Abstract17-Beta-estradiol (E2) stimulates neural plasticity and dopaminergic transmission in the prefrontal cortex, which is critically involved in attentional control, working memory, and other executive functions. Studies investigating E2 ’s actions on prefrontally mediated behavior in the course of the menstrual cycle or during hormone replacement therapy are inconclusive, with numerous null findings as well as beneficial and detrimental effects. The current study focused on the effect of E2 on attentional performance, as animal studies indicate that supraphysiological doses (i.e., above estrous cycle levels)...
Source: Psychopharmacology - Category: Psychiatry Source Type: research
Publication date: Available online 9 October 2018Source: Molecular and Cellular EndocrinologyAuthor(s): Craig S. Atwood, Samuel F. EksteinAbstractPrior to 2002, hormone replacement therapy (HRT) was considered to be an important component of postmenopausal healthcare. This was based on a plethora of basic, epidemiological and clinical studies demonstrating the health benefits of supplementation with human sex steroids. However, adverse findings from the Women's Health Initiative (WHI) studies that examined the 2 major forms of HRT in use in the US at that time - Premarin (conjugated equine estrogens; CEE) and Prempro (CEE&...
Source: Molecular and Cellular Endocrinology - Category: Endocrinology Source Type: research
This study does not support the existence of an important association between plasma concentrations of endogenous testosterone, DHEAS or SHBG with risk of VTE in middle-aged to older men or post-menopausal women not using HRT. PMID: 30296818 [PubMed - as supplied by publisher]
Source: Thrombosis and Haemostasis - Category: Hematology Authors: Tags: Thromb Haemost Source Type: research
Publication date: Available online 6 October 2018Source: Reproductive BioMedicine OnlineAuthor(s): Birgit Alsbjerg, Lise Thomsen, Helle O Elbaek, Rita Laursen, Betina B Povlsen, Thor Haahr, Peter HumaidanAbstract Research question: Do serum progesterone levels determine ongoing pregnancy rates (OPR) in hormone replacement therapy frozen–thawed embryo transfer (HRT–FET) cycles?Design: A cohort study of 244 HRT–FET cycles from a Danish public fertility centre. Data from patients undergoing HRT–FET from January 2016 to December 2017 were extracted from a clinical database. All patients had transfer in ...
Source: Reproductive BioMedicine Online - Category: Reproduction Medicine Source Type: research
Conclusion: Cardiovascular risk in Turner syndrome can be reduced using educational approaches to a healthy lifestyle with dietary guidelines. Besides this, we also recommend measuring HoloTC for the prompt detection of B12 defi ciency and to consider hormone replacement therapy in the biochemical assessment of homocysteine in TS.
Source: Medical Principles and Practice - Category: Internal Medicine Source Type: research
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