Effect of Gambogenic Acid on Cytochrome P450  1A2, 2B1 and 2E1, and Constitutive Androstane Receptor in Rats

ConclusionsThe obtained results suggest that the CYP1A2 and CYP2E1 enzymes could be induced in rats after treatment with GNA. Therefore, when GNA is administrated with other drugs, potential drug –drug interactions (DDI) mediated by CYP1A2 and CYP2E1 induction should be taken into consideration.
Source: European Journal of Drug Metabolism and Pharmacokinetics - Category: Drugs & Pharmacology Source Type: research