Pain inhibits itch, but not in atopic dermatitis?

We read with great interest the article by Vakharia et al1 in a recent issue of the Annals. The prospective study comprehensively addresses an overlooked aspect of the sensory symptoms associated with atopic dermatitis (AD). In 305 patients with AD, the study reported that pain was found in 42.7% and that 30.2% rated the cutaneous pain intensity as being moderate to very severe. This pain incidence is aligned with a previous study on the AD itch characteristics.2 Vakharia et al1 consistently found cutaneous pain to be associated with reduced quality of life (including: Patient-Oriented Eczema Measure, ItchyQOL, and Dermatology Life Quality Index) and to a lesser extent with objective disease severity.
Source: Annals of Allergy, Asthma and Immunology - Category: Allergy & Immunology Authors: Tags: Correspondence Source Type: research

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ConclusionThough the complication rate was found to be higher than most of the other studies, they were minor which resolved without any intervention. The cases with complications were clustered at the beginning of the series which suggests the steep learning curve and the importance of surgeons ’ experience and skill involved in this procedure.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
ConclusionThe ease of mobilization, superior blood supply and minimal donor site morbidity make it an ideal flap and a reliable alternative when other techniques fail.
Source: Journal of Maxillofacial and Oral Surgery - Category: ENT & OMF Source Type: research
In this issue, Tang et al. [1] from Taiwan report on an increasingly important issue in thoracic medicine and surgery, the natural history of small, asymptomatic lung nodules. The widespread use, over the last couple of decades, of increasingly sensitive computed tomography (CT) scans with reducing radiation dose has resulted in the recognition of a significant population of otherwise healthy patients who have a lung nodule of undefined nature. In most cases, this lung nodule has been detected at the time of a CT scan for a completely different issue —atypical chest pain, back pain, shoulder pain, and often for inves...
Source: Heart, Lung and Circulation - Category: Cardiology Authors: Tags: Editorial Source Type: research
Authors: Cruz FF, Rocco PRM Abstract Introduction: Mesenchymal stem/stromal cells (MSCs) have been shown to improve lung function and survival in chronic inflammatory lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis (IPF), pulmonary arterial hypertension (PAH), and silicosis. Areas covered: This review covers rationale for the use of MSC therapy, along with preclinical studies and clinical trials with MSC therapy in chronic lung diseases. Expert opinion: MSC therapy holds promise for the treatment of chronic lung diseases, mainly when administered at early...
Source: Expert Review of Respiratory Medicine - Category: Respiratory Medicine Tags: Expert Rev Respir Med Source Type: research
Conclusions: Pravastatin treatment in obese asthmatic mice suppressed allergic airway infiltration and AHR by inhibition of Th2 and Th17-associated signaling pathways, decreasing the leptin expression and downstream p38 MAPK signaling pathways. The effect on lean asthmatic mice was different, independent of airway cell counts and cytokines. PMID: 31608695 [PubMed - as supplied by publisher]
Source: Experimental Lung Research - Category: Respiratory Medicine Tags: Exp Lung Res Source Type: research
Authors: Ryan KS, Son S, Roddy M, Siraj S, McKinley SD, Nakagawa TA, Sochet AA Abstract Objective: To determine if the Pediatric Asthma Severity Score (PASS) can distinguish "late-rescues" (transfer to the pediatric intensive care unit [PICU] within 24-hours of general pediatric floor admission), "PICU readmissions" (readmission within 24-hours after transfer to a lower inpatient level of care), and unplanned 30-day hospital readmission in children admitted with status asthmaticus. Methods: We performed a single center, retrospective cohort study in 328 children admitted for asthma exacerbation ...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Conclusions: By analyzing medication sequence patterns for the ED encounter of pediatric asthma, we found that the earlier sequence placement of glucocorticoids administration is associated with improved outcomes. Our findings can help inform quality improvement and clinical guideline development related to ED asthma care for children. PMID: 31607182 [PubMed - as supplied by publisher]
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Authors: Averell CM, Stanford RH, Laliberté F, Wu JW, Germain G, Duh MS Abstract Objective: This real-world observational study compared medication adherence and persistence among patients with asthma receiving the once-daily inhaled corticosteroid/long-acting β2-agonist (ICS/LABA) fluticasone furoate/vilanterol (FF/VI) versus the twice-daily ICS/LABAs budesonide/formoterol (B/F) and fluticasone propionate/salmeterol (FP/SAL). Methods: This retrospective cohort study conducted using IQVIATM Health Plan Claims Data included patients with asthma ≥18 years of age initiating ICS/LABA therapy with ...
Source: Journal of Asthma - Category: Respiratory Medicine Tags: J Asthma Source Type: research
Authors: Wrigley J, Carden V, von Isenburg M Abstract This project characterized current research and collaboration patterns in pain research at one institution after researchers working on a grant application approached the library to better understand current institutional research and publishing about that topic. To address this question, library staff developed a collaborative, multi-tool process for bibliometric analysis and network visualization. The primary data source used was a preexisting, curated EndNote library of institutional publications. This EndNote library was searched using keywords relevant to t...
Source: Journal of the Medical Library Association : JMLA - Category: Databases & Libraries Tags: J Med Libr Assoc Source Type: research
Authors: Oderda GM, Senagore AJ, Morland K, Iqbal SU, Kugel M, Liu S, Habib AS Abstract Opioid-induced respiratory depression (OIRD) and postoperative nausea and vomiting (PONV) are challenging, resource-intensive, and costly opioid-related adverse events (ORAEs). Utilizing the Premier Healthcare Database, we identified patients> 18 years old, who underwent at least one surgical procedure of interest (i.e., cardiothoracic/vascular, general/colorectal, obstetric/gynecologic, orthopedic, or urologic), and received at least one dose of intravenous morphine, hydromorphone, or fentanyl for acute postoperative ...
Source: Journal of Pain and Palliative Care Pharmacotherapy - Category: Palliative Care Tags: J Pain Palliat Care Pharmacother Source Type: research
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