Gut immunity: its development and reasons and opportunities for modulation in monogastric production animals.

Gut immunity: its development and reasons and opportunities for modulation in monogastric production animals. Anim Health Res Rev. 2018 Apr 29;:1-7 Authors: Broom LJ, Kogut MH Abstract The intestine performs the critical roles of nutrient acquisition, tolerance of innocuous and beneficial microorganisms, while retaining the ability to respond appropriately to undesirable microbes or microbial products and preventing their translocation to more sterile body compartments. Various components contribute to antimicrobial defenses in the intestine. The mucus layer(s), antimicrobial peptides and IgA provide the first line of defense, and seek to trap and facilitate the removal of invading microbes. If breached, invading microbes next encounter a single layer of epithelial cells and, below this, the lamina propria with its associated immune cells. The gut immune system has developmental stages, and studies from different species demonstrate that innate capability develops earlier than acquired. In addition, various factors may influence the developmental process; for example, the composition and activity of the gut microbiota, antimicrobials, maternally derived antibodies, host genetics, and various stressors (e.g. feed deprivation). Therefore, it is clear that particularly younger (meat-producing) animals are reliant on innate immune responses (as well as passive immunity) for a considerable period of their productive life, and thus focusin...
Source: Animal Health Research Reviews - Category: Veterinary Research Authors: Tags: Anim Health Res Rev Source Type: research